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- Q7846271 subject Q8388304.
- Q7846271 subject Q8919936.
- Q7846271 abstract "Tropoxane is an aryloxytropane derivative drug developed by Organix Inc., which acts as a stimulant and potent dopamine and serotonin reuptake inhibitor. It is an analogue of dichloropane where the amine nitrogen has been replaced by an oxygen ether link (at the bridgehead position), demonstrating that the amine nitrogen is not required for DAT binding and reuptake inhibition.P. Meltzer, et al. made some 8-thiabicyclo(3.2.1)octanes recently (2007).For SAR purposes, a table has been included that lists some of these compounds.It had been hypothesized that transporter binding of the tropanes might include ionic bonding of the central tropane nitrogen. But it turned out that at this site neither ionic nor hydrogen bonding is a prerequisite for potent monoamine reuptake inhibition. Oxa- and thia-analogs of RTI-111 are potent inhibitors, and even an N-replacement by methylene holds the potency within the same magnitude. However, N-quaternisation (N-dimethyl) considerably reduces DAT affinity.".
- Q7846271 atcPrefix "none".
- Q7846271 iupacName "methyl (1R,2S,3S,5S)-3-(3,4-dichlorophenyl)-8-oxabicyclo[3.2.1]octane-2-carboxylate".
- Q7846271 pubchem "9796921".
- Q7846271 thumbnail Tropoxane.png?width=300.
- Q7846271 wikiPageExternalLink picrender.fcgi?artid=1829488&blobtype=pdf.
- Q7846271 wikiPageWikiLink Q103230.
- Q7846271 wikiPageWikiLink Q11172462.
- Q7846271 wikiPageWikiLink Q14865372.
- Q7846271 wikiPageWikiLink Q167198.
- Q7846271 wikiPageWikiLink Q167934.
- Q7846271 wikiPageWikiLink Q169324.
- Q7846271 wikiPageWikiLink Q170304.
- Q7846271 wikiPageWikiLink Q211036.
- Q7846271 wikiPageWikiLink Q4859664.
- Q7846271 wikiPageWikiLink Q5272482.
- Q7846271 wikiPageWikiLink Q62500.
- Q7846271 wikiPageWikiLink Q6610369.
- Q7846271 wikiPageWikiLink Q7071997.
- Q7846271 wikiPageWikiLink Q8388304.
- Q7846271 wikiPageWikiLink Q8919936.
- Q7846271 wikiPageWikiLink Q996524.
- Q7846271 atcPrefix "none".
- Q7846271 iupacName "methyl -3--8-oxabicyclo[3.2.1]octane-2-carboxylate".
- Q7846271 pubchem "9796921".
- Q7846271 type ChemicalSubstance.
- Q7846271 type Drug.
- Q7846271 type ChemicalObject.
- Q7846271 type Thing.
- Q7846271 type Q8386.
- Q7846271 comment "Tropoxane is an aryloxytropane derivative drug developed by Organix Inc., which acts as a stimulant and potent dopamine and serotonin reuptake inhibitor. It is an analogue of dichloropane where the amine nitrogen has been replaced by an oxygen ether link (at the bridgehead position), demonstrating that the amine nitrogen is not required for DAT binding and reuptake inhibition.P. Meltzer, et al.".
- Q7846271 label "Tropoxane".
- Q7846271 depiction Tropoxane.png.