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- Q7843332 subject Q8310878.
- Q7843332 abstract "Triple-negative breast cancer (sometimes abbreviated TNBC) refers to any breast cancer that does not express the genes for estrogen receptor (ER), progesterone receptor (PR) or Her2/neu. This makes it more difficult to treat since most chemotherapies target one of the three receptors, so triple-negative cancers often require combination therapies. Triple negative is sometimes used as a surrogate term for basal-like; however, more detailed classification may provide better guidance for treatment and better estimates for prognosis.Triple-negative breast cancers comprise a very heterogeneous group of cancers. There is conflicting information over prognosis for the various subtypes but it appears that the Nottingham prognostic index is valid and hence general prognosis is rather similar with other breast cancer of same stage, except that more aggressive treatment is required. Some types of triple-negative breast cancer are known to be more aggressive with poor prognoses, while other types have very similar or better prognoses than hormone receptor positive breast cancers. Pooled data of all triple-negative subtypes suggest that with optimal treatment 20-year survival rates are very close to those of hormone positive cancer.Triple-negative breast cancers have a relapse pattern that is very different from hormone-positive breast cancers: the risk of relapse is much higher for the first 3–5 years but drops sharply and substantially below that of hormone-positive breast cancers after that. This relapse pattern has been recognized for all types of triple-negative cancers for which sufficient data exists although the absolute relapse and survival rates differ across subtypes.".
- Q7843332 wikiPageExternalLink www.tnbcfoundation.org.
- Q7843332 wikiPageWikiLink Q128581.
- Q7843332 wikiPageWikiLink Q14763023.
- Q7843332 wikiPageWikiLink Q14865565.
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- Q7843332 wikiPageWikiLink Q14877486.
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- Q7843332 wikiPageWikiLink Q3771944.
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- Q7843332 wikiPageWikiLink Q6991934.
- Q7843332 wikiPageWikiLink Q7118227.
- Q7843332 wikiPageWikiLink Q7444455.
- Q7843332 wikiPageWikiLink Q7770259.
- Q7843332 wikiPageWikiLink Q8310878.
- Q7843332 wikiPageWikiLink Q961652.
- Q7843332 wikiPageWikiLink Q974135.
- Q7843332 comment "Triple-negative breast cancer (sometimes abbreviated TNBC) refers to any breast cancer that does not express the genes for estrogen receptor (ER), progesterone receptor (PR) or Her2/neu. This makes it more difficult to treat since most chemotherapies target one of the three receptors, so triple-negative cancers often require combination therapies.".
- Q7843332 label "Triple-negative breast cancer".
- Q7843332 homepage www.tnbcfoundation.org.