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- Q7835367 subject Q6276539.
- Q7835367 subject Q7153053.
- Q7835367 subject Q8824881.
- Q7835367 abstract "The transsulfuration pathway is a metabolic pathway involving the interconversion of cysteine and homocysteine, through the intermediate cystathionine.This is in contrast to the direct sulfurylation pathways for the synthesis of cysteine or homocysteine via the replacement of the acetyl/succinyl group with free sulfide (via the cysK or cysM -encoded cysteine synthase and the metZ or metY -encoded homocysteine synthase, respectively).Two transsulfurylation pathway are known, the forward pathway and the reverse.The forward pathway is present is several bacteria for example in Escherichia coli and Bacillus subtilis and involves the transfer of the thiol group from cysteine to homocysteine (methionine precursor with the S-methyl group), thanks to the γ-replacement of the acetyl or succinyl group of a homoserine ester with cysteine via its thiol group to form cystathionine (catalysed by cystathionine γ-synthase, which is encoded by metB in E. coli and metI in B. subtilis). Cystathionine is then cleaved by means of the β-elimination of the homocysteine portion of the molecule leaving behind an unstable imino acid, which is attacked by water to form pyruvate and ammonia (catalysed by the metC-encoded cystathionine β-lyase).The production of homocysteine through transsulfuration allows the conversion of this intermediate to methionine, through a methylation reaction carried out by methionine synthase.The reverse pathway is present in several organisms, including humans, and involves the transfer of the thiol group from homocysteine to cysteine via a similar mechanism. In Klebsiella pneumoniae the cystathionine β-synthase is encoded by mtcB, while the γ-lyase is encoded by mtcC.Humans are auxotrophic for methionine, hence it is called an "essential amino acid" by nutritionists, but are not for cysteine due to the reverse trans-sulfurylation pathway. Mutations in this pathway lead to a disease known as homocystinuria.".
- Q7835367 thumbnail Met_pathway.gif?width=300.
- Q7835367 wikiPageWikiLink Q14876914.
- Q7835367 wikiPageWikiLink Q14913093.
- Q7835367 wikiPageWikiLink Q180341.
- Q7835367 wikiPageWikiLink Q186474.
- Q7835367 wikiPageWikiLink Q192466.
- Q7835367 wikiPageWikiLink Q452410.
- Q7835367 wikiPageWikiLink Q5201180.
- Q7835367 wikiPageWikiLink Q5201182.
- Q7835367 wikiPageWikiLink Q5201184.
- Q7835367 wikiPageWikiLink Q6276539.
- Q7835367 wikiPageWikiLink Q68685.
- Q7835367 wikiPageWikiLink Q7153053.
- Q7835367 wikiPageWikiLink Q8824881.
- Q7835367 wikiPageWikiLink Q935387.
- Q7835367 wikiPageWikiLink Q994859.
- Q7835367 comment "The transsulfuration pathway is a metabolic pathway involving the interconversion of cysteine and homocysteine, through the intermediate cystathionine.This is in contrast to the direct sulfurylation pathways for the synthesis of cysteine or homocysteine via the replacement of the acetyl/succinyl group with free sulfide (via the cysK or cysM -encoded cysteine synthase and the metZ or metY -encoded homocysteine synthase, respectively).Two transsulfurylation pathway are known, the forward pathway and the reverse.The forward pathway is present is several bacteria for example in Escherichia coli and Bacillus subtilis and involves the transfer of the thiol group from cysteine to homocysteine (methionine precursor with the S-methyl group), thanks to the γ-replacement of the acetyl or succinyl group of a homoserine ester with cysteine via its thiol group to form cystathionine (catalysed by cystathionine γ-synthase, which is encoded by metB in E. ".
- Q7835367 label "Transsulfuration pathway".
- Q7835367 depiction Met_pathway.gif.