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- Q7808816 subject Q7334131.
- Q7808816 subject Q8431645.
- Q7808816 subject Q8788410.
- Q7808816 subject Q8794193.
- Q7808816 subject Q8852392.
- Q7808816 abstract "Tipepidine (INN) (brand names Asverin, Antupex, Asvelik, Asvex, Bitiodin, Cofdenin A, Hustel, Nodal, Sotal), also known as tipepidine hibenzate (JAN), is a synthetic, non-opioid antitussive and expectorant of the thiambutene class. It acts as an inhibitor of G protein-coupled inwardly-rectifying potassium channels (GIRKs). The drug was discovered in the 1950s, and was developed in Japan in 1959. It is used as the hibenzate and citrate salts.The usual dose is 20 mg every 4–6 hours. Possible side effects of tipepidine, especially in overdose, may include drowsiness, vertigo, delirium, disorientation, loss of consciousness, and confusion.Tipepidine has recently garnered interest as a potential psychiatric drug. It is being investigated in depression, obsessive-compulsive disorder, and attention-deficit hyperactivity disorder (ADHD). Through inhibition of GIRK channels, tipepidine increases dopamine levels in the nucleus accumbens, but without increasing locomotor activity or producing methamphetamine-like behavioral sensitization, and this action appears to be at least partly responsible for its antidepressant-like effects in rodents.".
- Q7808816 atcPrefix "R05".
- Q7808816 atcSuffix "DB24".
- Q7808816 casNumber "5169-78-8".
- Q7808816 fdaUniiCode "2260ZP67IT".
- Q7808816 iupacName "3-(di-2-thienylmethylene)-1-methylpiperidine".
- Q7808816 pubchem "5484".
- Q7808816 thumbnail Tipepidine.svg?width=300.
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- Q7808816 wikiPageWikiLink Q7334131.
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- Q7808816 wikiPageWikiLink Q8431645.
- Q7808816 wikiPageWikiLink Q8788410.
- Q7808816 wikiPageWikiLink Q8794193.
- Q7808816 wikiPageWikiLink Q8852392.
- Q7808816 atcPrefix "R05".
- Q7808816 atcSuffix "DB24".
- Q7808816 casNumber "5169".
- Q7808816 iupacName "3".
- Q7808816 pubchem "5484".
- Q7808816 unii "2260".
- Q7808816 type ChemicalSubstance.
- Q7808816 type Drug.
- Q7808816 type ChemicalObject.
- Q7808816 type Thing.
- Q7808816 type Q8386.
- Q7808816 comment "Tipepidine (INN) (brand names Asverin, Antupex, Asvelik, Asvex, Bitiodin, Cofdenin A, Hustel, Nodal, Sotal), also known as tipepidine hibenzate (JAN), is a synthetic, non-opioid antitussive and expectorant of the thiambutene class. It acts as an inhibitor of G protein-coupled inwardly-rectifying potassium channels (GIRKs). The drug was discovered in the 1950s, and was developed in Japan in 1959. It is used as the hibenzate and citrate salts.The usual dose is 20 mg every 4–6 hours.".
- Q7808816 label "Tipepidine".
- Q7808816 depiction Tipepidine.svg.