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- Q7783869 subject Q8645495.
- Q7783869 subject Q8852392.
- Q7783869 subject Q8878420.
- Q7783869 subject Q8887197.
- Q7783869 abstract "The Thiambutenes are a family of opioid analgesic drugs developed at the British research laboratory of Burroughs-Wellcome in the late 1940s. The parent compound thiambutene has no analgesic effects, but several compounds from this group are analgesics with around the same potency as morphine.Notable compounds include dimethylthiambutene, diethylthiambutene, ethylmethylthiambutene, pyrrolidinylthiambutene and piperidylthiambutene. Of these, ethylmethylthiambutene is the most potent, with 1.3x the potency of morphine, pyrrolidinylthiambutene is the least potent at 0.7x, and the rest are all around the same potency as morphine. Diethylthiambutene has been the most widely used, mainly in veterinary medicine.All of these compounds produced anticholinergic and antihistamine side effects, except for two of the weaker compounds diallylthiambutene and morpholinylthiambutene. They also all have a chiral centre on the alpha carbon (where the R1 group is attached) and so have two stereoisomers, with the dextro isomer being the more potent in all cases, although both isomers are active.Three of these compounds are explicitly listed as illegal drugs under UN convention, diethylthiambutene, dimethylthiambutene and ethylmethylthiambutene, and so are illegal throughout the world, but the rest will only be illegal in countries such as the USA, Australia and New Zealand that have laws equivalent to the Federal Analog Act.160px".
- Q7783869 atcPrefix "none".
- Q7783869 iupacName "(RS)-4,4-dithiophen-2-yl-but-3-en-2-amine".
- Q7783869 thumbnail Thiambutene.png?width=300.
- Q7783869 wikiPageWikiLink Q10489450.
- Q7783869 wikiPageWikiLink Q113259.
- Q7783869 wikiPageWikiLink Q1371525.
- Q7783869 wikiPageWikiLink Q170201.
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- Q7783869 wikiPageWikiLink Q408898.
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- Q7783869 wikiPageWikiLink Q427523.
- Q7783869 wikiPageWikiLink Q43413.
- Q7783869 wikiPageWikiLink Q4407.
- Q7783869 wikiPageWikiLink Q467717.
- Q7783869 wikiPageWikiLink Q5275150.
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- Q7783869 wikiPageWikiLink Q5440009.
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- Q7783869 wikiPageWikiLink Q7263770.
- Q7783869 wikiPageWikiLink Q81225.
- Q7783869 wikiPageWikiLink Q8645495.
- Q7783869 wikiPageWikiLink Q8852392.
- Q7783869 wikiPageWikiLink Q8878420.
- Q7783869 wikiPageWikiLink Q8887197.
- Q7783869 wikiPageWikiLink Q898637.
- Q7783869 atcPrefix "none".
- Q7783869 drugName "Thiambutene".
- Q7783869 iupacName "-44".
- Q7783869 type ChemicalSubstance.
- Q7783869 type Drug.
- Q7783869 type ChemicalObject.
- Q7783869 type Thing.
- Q7783869 type Q8386.
- Q7783869 comment "The Thiambutenes are a family of opioid analgesic drugs developed at the British research laboratory of Burroughs-Wellcome in the late 1940s. The parent compound thiambutene has no analgesic effects, but several compounds from this group are analgesics with around the same potency as morphine.Notable compounds include dimethylthiambutene, diethylthiambutene, ethylmethylthiambutene, pyrrolidinylthiambutene and piperidylthiambutene.".
- Q7783869 label "Thiambutenes".
- Q7783869 depiction Thiambutene.png.
- Q7783869 name "Thiambutene".