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- Q7706740 subject Q5016550.
- Q7706740 subject Q7069096.
- Q7706740 subject Q7348581.
- Q7706740 subject Q9089708.
- Q7706740 abstract "Tetraspanins are a family of membrane proteins found in all multicellular eukaryotes.Tetraspanins, also called tetraspans or the transmembrane 4 superfamily (TM4SF), have four transmembrane domains, intracellular N- and C-termini and two extracellular domains, one short (called the small extracellular domain or loop, SED/SEL or EC1) and one longer, typically 100 amino acid residues (the large extracellular domain/loop, LED/LEL or EC2). Although several protein families have four transmembrane domains, tetraspanins are defined by conserved domains listed in the Protein Families database under pfam00335.12. The key features are four or more cysteine residues in the EC2 domain, with two in a highly conserved 'CCG' motif.Research into this field is relatively recent (less than 20 years) and therefore there is much to learn about the function of specific tetraspanins. Generally, tetraspanins are often thought to act as scaffolding proteins, anchoring multiple proteins to one area of the cell membrane.Tetraspanins are highly conserved between species. Some tetraspanins can have N-linked glycosylations on the long extracellular loop (LEL, EC2) and palmitoylations at a CXXC motif in their transmembrane region.There are 34 tetraspanins in mammals, 33 of which have also been identified in humans. Tetraspanins display numerous properties that indicate their physiological importance in cell adhesion, motility, activation and proliferation, as well as their contribution to pathological conditions such as metastasis or viral infection.A role for tetraspanins in platelets was demonstrated by the bleeding phenotypes of CD151- and TSSC6-deficient mice, which exhibit impaired "outside-in" signalling through αIIbβ3, the major platelet integrin. it is hypothesized that tetraspanins interact with and regulate other platelet receptors.".
- Q7706740 symbol "Tetraspanin".
- Q7706740 thumbnail Tetraspanin_Figure.jpg?width=300.
- Q7706740 wikiPageExternalLink IEntry?ac=IPR008952.
- Q7706740 wikiPageExternalLink Tetraspanin-table.doc.
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- Q7706740 wikiPageWikiLink Q501620.
- Q7706740 wikiPageWikiLink Q5016550.
- Q7706740 wikiPageWikiLink Q7069096.
- Q7706740 wikiPageWikiLink Q7348581.
- Q7706740 wikiPageWikiLink Q898365.
- Q7706740 wikiPageWikiLink Q906796.
- Q7706740 wikiPageWikiLink Q9089708.
- Q7706740 symbol "Tetraspanin".
- Q7706740 type Biomolecule.
- Q7706740 type Protein.
- Q7706740 type Thing.
- Q7706740 type Q206229.
- Q7706740 type Q8054.
- Q7706740 comment "Tetraspanins are a family of membrane proteins found in all multicellular eukaryotes.Tetraspanins, also called tetraspans or the transmembrane 4 superfamily (TM4SF), have four transmembrane domains, intracellular N- and C-termini and two extracellular domains, one short (called the small extracellular domain or loop, SED/SEL or EC1) and one longer, typically 100 amino acid residues (the large extracellular domain/loop, LED/LEL or EC2).".
- Q7706740 label "Tetraspanin".
- Q7706740 depiction Tetraspanin_Figure.jpg.