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- Q7662758 subject Q4925926.
- Q7662758 subject Q9990766.
- Q7662758 abstract "Synthetic Genetic Array analysis (SGA) is a high-throughput technique for exploring synthetic lethal and synthetic sick genetic interactions (SSL). SGA allows for the systematic construction of double mutants using a combination of recombinant genetic techniques, mating and selection steps. Using SGA methodology a query gene deletion mutant can be crossed to an entire genome deletion set to identify any SSL interactions, yielding functional information of the query gene and the genes it interacts with. A large-scale application of SGA in which ~130 query genes were crossed to the set of ~5000 viable deletion mutants in yeast revealed a genetic network containing ~1000 genes and ~4000 SSL interactions. The results of this study showed that genes with similar function tend to interact with one another and genes with similar patterns of genetic interactions often encode products that tend to work in the same pathway or complex. Synthetic Genetic Array analysis was initially developed using the model organism S.cerevisiae. This method has since been extended to cover 30% of the S. cerevisiae genome. Methodology has since been developed to allow SGA analysis in S.pombe and E.coli.".
- Q7662758 thumbnail Yeast_colonies_array_1536_format.jpg?width=300.
- Q7662758 wikiPageWikiLink Q118406.
- Q7662758 wikiPageWikiLink Q1337844.
- Q7662758 wikiPageWikiLink Q2236682.
- Q7662758 wikiPageWikiLink Q285697.
- Q7662758 wikiPageWikiLink Q4925926.
- Q7662758 wikiPageWikiLink Q626251.
- Q7662758 wikiPageWikiLink Q719725.
- Q7662758 wikiPageWikiLink Q751748.
- Q7662758 wikiPageWikiLink Q7662767.
- Q7662758 wikiPageWikiLink Q7706297.
- Q7662758 wikiPageWikiLink Q908550.
- Q7662758 wikiPageWikiLink Q9990766.
- Q7662758 comment "Synthetic Genetic Array analysis (SGA) is a high-throughput technique for exploring synthetic lethal and synthetic sick genetic interactions (SSL). SGA allows for the systematic construction of double mutants using a combination of recombinant genetic techniques, mating and selection steps.".
- Q7662758 label "Synthetic genetic array".
- Q7662758 depiction Yeast_colonies_array_1536_format.jpg.