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- Q7531735 subject Q7469321.
- Q7531735 abstract "Nearly every human gene has a counterpart in the mouse (regardless of the fact that a minor set of orthologues had to follow species specific selection routes). This made the mouse the major model for elucidating the ways in which our genetic material encodes information. In the late 1980s gene targeting in murine embryonic stem (ES-)cells enabled the transmission of mutations into the mouse germ line and emerged as a novel option to study the genetic basis of regulatory networks as they exist in the genome. Still, classical gene targeting proved to be limited in several ways as gene functions became irreversibly destroyed by the marker gene that had to be introduced for selecting recombinant ES cells. These early steps led to animals in which the mutation was present in all cells of the body from the beginning leading to complex phenotypes and/or early lethality. There was a clear need for methods to restrict these mutations to specific points in development and specific cell types. This dream became reality when groups in the USA were able to introduce bacteriophage and yeast-derived site-specific recombination (SSR-) systems into mammalian cells as well as into the mouse".
- Q7531735 thumbnail Classification_of_site-specific_recombinases_according_to_mechanism.png?width=300.
- Q7531735 wikiPageExternalLink 701.long.
- Q7531735 wikiPageExternalLink www.knockoutmouse.org.
- Q7531735 wikiPageWikiLink Q1151519.
- Q7531735 wikiPageWikiLink Q165028.
- Q7531735 wikiPageWikiLink Q169953.
- Q7531735 wikiPageWikiLink Q187388.
- Q7531735 wikiPageWikiLink Q193161.
- Q7531735 wikiPageWikiLink Q211083.
- Q7531735 wikiPageWikiLink Q211675.
- Q7531735 wikiPageWikiLink Q2124342.
- Q7531735 wikiPageWikiLink Q218447.
- Q7531735 wikiPageWikiLink Q224093.
- Q7531735 wikiPageWikiLink Q224180.
- Q7531735 wikiPageWikiLink Q277954.
- Q7531735 wikiPageWikiLink Q285982.
- Q7531735 wikiPageWikiLink Q28962.
- Q7531735 wikiPageWikiLink Q410943.
- Q7531735 wikiPageWikiLink Q412178.
- Q7531735 wikiPageWikiLink Q416496.
- Q7531735 wikiPageWikiLink Q465621.
- Q7531735 wikiPageWikiLink Q47273.
- Q7531735 wikiPageWikiLink Q4994856.
- Q7531735 wikiPageWikiLink Q5426559.
- Q7531735 wikiPageWikiLink Q674925.
- Q7531735 wikiPageWikiLink Q7187.
- Q7531735 wikiPageWikiLink Q7469321.
- Q7531735 wikiPageWikiLink Q7531737.
- Q7531735 wikiPageWikiLink Q79899.
- Q7531735 wikiPageWikiLink Q908966.
- Q7531735 wikiPageWikiLink Q916698.
- Q7531735 comment "Nearly every human gene has a counterpart in the mouse (regardless of the fact that a minor set of orthologues had to follow species specific selection routes). This made the mouse the major model for elucidating the ways in which our genetic material encodes information.".
- Q7531735 label "Site-specific recombinase technology".
- Q7531735 depiction Classification_of_site-specific_recombinases_according_to_mechanism.png.