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- Q7459764 subject Q8680982.
- Q7459764 abstract "SgrS (sugar transport-related sRNA, previously named ryaA) is a 227 nucleotide small RNA that is activated by SgrR in Escherichia coli during glucose-phosphate stress. The nature of glucose-phosphate stress is not fully understood, but is correlated with intracellular accumulation of glucose-6-phosphate. SgrS helps cells recover from glucose-phosphate stress by base pairing with ptsG mRNA (encoding the glucose transporter) and causing its degradation in an RNase E dependent manner. Base pairing between SgrS and ptsG mRNA also requires Hfq, an RNA chaperone frequently required by small RNAs that affect their targets through base pairing. The inability of cells expressing sgrS to create new glucose transporters leads to less glucose uptake and reduced levels of glucose-6-phosphate. SgrS is an unusual small RNA in that it also encodes a 43 amino acid functional polypeptide, SgrT, which helps cells recover from glucose-phosphate stress by preventing glucose uptake. The activity of SgrT does not affect the levels of ptsG mRNA of PtsG protein. It has been proposed that SgrT exerts its effects through regulation of the glucose transporter, PtsG.SgrS was originally discovered in E. coli but homologues have since been identified in other Gammaproteobacteria such as Salmonella enterica and members of the Citrobacter genus. A comparative genomics based target prediction approach that employs these homologs, has been developed and was used to predict the SgrS target, ptsI (b2416), which was subsequently verified experimentally.".
- Q7459764 thumbnail RF00534.jpg?width=300.
- Q7459764 wikiPageExternalLink gene_query.php?acc=sRNAG0056.
- Q7459764 wikiPageExternalLink mb1E.html.
- Q7459764 wikiPageExternalLink 1543.
- Q7459764 wikiPageWikiLink Q10876.
- Q7459764 wikiPageWikiLink Q134081.
- Q7459764 wikiPageWikiLink Q134668.
- Q7459764 wikiPageWikiLink Q15712714.
- Q7459764 wikiPageWikiLink Q17148058.
- Q7459764 wikiPageWikiLink Q188928.
- Q7459764 wikiPageWikiLink Q224180.
- Q7459764 wikiPageWikiLink Q2264864.
- Q7459764 wikiPageWikiLink Q25419.
- Q7459764 wikiPageWikiLink Q37525.
- Q7459764 wikiPageWikiLink Q407962.
- Q7459764 wikiPageWikiLink Q423832.
- Q7459764 wikiPageWikiLink Q427087.
- Q7459764 wikiPageWikiLink Q4995178.
- Q7459764 wikiPageWikiLink Q7187.
- Q7459764 wikiPageWikiLink Q8066.
- Q7459764 wikiPageWikiLink Q8680982.
- Q7459764 comment "SgrS (sugar transport-related sRNA, previously named ryaA) is a 227 nucleotide small RNA that is activated by SgrR in Escherichia coli during glucose-phosphate stress. The nature of glucose-phosphate stress is not fully understood, but is correlated with intracellular accumulation of glucose-6-phosphate. SgrS helps cells recover from glucose-phosphate stress by base pairing with ptsG mRNA (encoding the glucose transporter) and causing its degradation in an RNase E dependent manner.".
- Q7459764 label "SgrS RNA".
- Q7459764 depiction RF00534.jpg.