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- Q7448011 subject Q6155998.
- Q7448011 subject Q7703775.
- Q7448011 subject Q8234370.
- Q7448011 subject Q8390757.
- Q7448011 subject Q8823530.
- Q7448011 abstract "Self-administration is, in its medical sense, the process of a subject administering a pharmacological substance to him-, her-, or itself. A clinical example of this is the subcutaneous "self-injection" of insulin by a diabetic patient.In animal experimentation, self-administration is a form of operant conditioning where the reward is a drug. This drug can be administered remotely through an implanted intravenous line or an intracerebroventricular injection. Self-administration of putatively addictive drugs is considered one of the most valid experimental models to investigate drug-seeking and drug-taking behavior. The higher the frequency with which a test animal emits the operant behavior, the more rewarding (and addictive), the test substance is considered. Self-administration of addictive drugs has been studied using humans, non-human primates, mice, and, most commonly, rats.Self-administration of heroin and cocaine is used to screen drugs for possible effects in reducing drug-taking behavior, especially reinstatement of drug seeking after extinction. Drugs with this effect may be useful for treating people with drug addiction by helping them establish abstinence or reducing their probability or relapsing to drug use after a period of abstinence.In a prominent model of self-administration developed by George Koob, rats are allowed to self-administer cocaine for either 1 hour each day (short access) or 6 hours each day (long access). Those animals who are allowed to self-administer for 6 hours a day show behavior that is thought to resemble cocaine dependence, such as an escalation of the total dose taken during each session and an increase in the dose taken when cocaine is first made available.".
- Q7448011 wikiPageWikiLink Q11190.
- Q7448011 wikiPageWikiLink Q12029.
- Q7448011 wikiPageWikiLink Q12206.
- Q7448011 wikiPageWikiLink Q128406.
- Q7448011 wikiPageWikiLink Q1321905.
- Q7448011 wikiPageWikiLink Q1385098.
- Q7448011 wikiPageWikiLink Q182413.
- Q7448011 wikiPageWikiLink Q21163221.
- Q7448011 wikiPageWikiLink Q2292472.
- Q7448011 wikiPageWikiLink Q38344.
- Q7448011 wikiPageWikiLink Q5541413.
- Q7448011 wikiPageWikiLink Q6155998.
- Q7448011 wikiPageWikiLink Q7703775.
- Q7448011 wikiPageWikiLink Q8234370.
- Q7448011 wikiPageWikiLink Q8390757.
- Q7448011 wikiPageWikiLink Q847079.
- Q7448011 wikiPageWikiLink Q8823530.
- Q7448011 comment "Self-administration is, in its medical sense, the process of a subject administering a pharmacological substance to him-, her-, or itself. A clinical example of this is the subcutaneous "self-injection" of insulin by a diabetic patient.In animal experimentation, self-administration is a form of operant conditioning where the reward is a drug. This drug can be administered remotely through an implanted intravenous line or an intracerebroventricular injection.".
- Q7448011 label "Self-administration".