Matches in DBpedia 2016-04 for { <http://wikidata.dbpedia.org/resource/Q7404461> ?p ?o }
Showing triples 1 to 39 of
39
with 100 triples per page.
- Q7404461 subject Q7427150.
- Q7404461 subject Q8699456.
- Q7404461 subject Q8789452.
- Q7404461 abstract "Salicylhydroxamic acid (SHA or SHAM) is a drug that is a potent and irreversible inhibitor of bacterial and plant urease usually used for urinary tract infections. The molecule is similar to urea but is not hydrolyzable by the urease enzyme. It is also a trypanocidal agent. When administered orally, it is metabolized to salicylamide which exerts analgesic, antipyretic and antiinflammatory effects.Salicylhydroxamic acid is also a common ligand utilized in the synthesis of metallacrowns.In plants, some fungi and some protists with the alternative oxidase (AOX) enzyme in the mitochondrial electron transport chain system, salicylhdroxamic acid acts as an inhibitor of the enzyme, blocking the largely uninhibited flow of electrons through AOX. AOX acts as a "short circuit" of the normal electron chain, dissipating electrons with a much-decreased translocation of protons, and therefore diminished production of ATP by oxidative phosphorylation. When AOX is blocked by SHAM, electrons are forced through the cytochrome pathway and through cytochrome IV, allowing observation of the operation of the cytochrome pathway without AOX activity. The AOX pathway is found to be the exclusive electron transport pathway in Trypanosoma brucei, the organism that causes African Sleeping Sickness, meaning that SHAM completely shuts down oxygen consumption by this organism.".
- Q7404461 iupacName "2-Hydroxybenzenecarbohydroxamic acid".
- Q7404461 thumbnail Salicylhydroxamic_acid.png?width=300.
- Q7404461 wikiPageWikiLink Q10876.
- Q7404461 wikiPageWikiLink Q1419820.
- Q7404461 wikiPageWikiLink Q166231.
- Q7404461 wikiPageWikiLink Q173235.
- Q7404461 wikiPageWikiLink Q181100.
- Q7404461 wikiPageWikiLink Q193161.
- Q7404461 wikiPageWikiLink Q203133.
- Q7404461 wikiPageWikiLink Q211016.
- Q7404461 wikiPageWikiLink Q227564.
- Q7404461 wikiPageWikiLink Q2496906.
- Q7404461 wikiPageWikiLink Q285166.
- Q7404461 wikiPageWikiLink Q33244.
- Q7404461 wikiPageWikiLink Q423237.
- Q7404461 wikiPageWikiLink Q481822.
- Q7404461 wikiPageWikiLink Q48318.
- Q7404461 wikiPageWikiLink Q581996.
- Q7404461 wikiPageWikiLink Q582687.
- Q7404461 wikiPageWikiLink Q6822815.
- Q7404461 wikiPageWikiLink Q7427150.
- Q7404461 wikiPageWikiLink Q756.
- Q7404461 wikiPageWikiLink Q7848571.
- Q7404461 wikiPageWikiLink Q8386.
- Q7404461 wikiPageWikiLink Q8699456.
- Q7404461 wikiPageWikiLink Q8789452.
- Q7404461 iupacname "2".
- Q7404461 type ChemicalCompound.
- Q7404461 type ChemicalSubstance.
- Q7404461 type ChemicalObject.
- Q7404461 type Thing.
- Q7404461 type Q11173.
- Q7404461 comment "Salicylhydroxamic acid (SHA or SHAM) is a drug that is a potent and irreversible inhibitor of bacterial and plant urease usually used for urinary tract infections. The molecule is similar to urea but is not hydrolyzable by the urease enzyme. It is also a trypanocidal agent.".
- Q7404461 label "Salicylhydroxamic acid".
- Q7404461 depiction Salicylhydroxamic_acid.png.