Matches in DBpedia 2016-04 for { <http://wikidata.dbpedia.org/resource/Q7372445> ?p ?o }
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- Q7372445 subject Q7139608.
- Q7372445 subject Q7335370.
- Q7372445 subject Q8546974.
- Q7372445 abstract "Roxindole (EMD-49,980) is a dopaminergic and serotonergic drug which was originally developed for the treatment of schizophrenia. In clinical trials its antipsychotic efficacy was only modest but it was unexpectedly found to produce potent and rapid antidepressant and anxiolytic effects. As a result, roxindole was further researched for the treatment of depression instead. It has also been investigated as a therapy for Parkinson's disease and prolactinoma.Roxindole acts as an agonist at the following receptors: D2 receptor (pKi = 8.55) D3 receptor (pKi = 8.93) D4 receptor (pKi = 8.23) 5-HT1A receptor (pKi = 9.42)At D2 and possibly D3 receptors roxindole is a partial agonist with preferential actions at autoreceptors and has been touted as a 'selective' autoreceptor agonist, hence the justification of its application as an antipsychotic. Weaker activity at the serotonin 1B and 1D receptors has been seen. It is also a serotonin reuptake inhibitor (IC50 = 1.4 nM) and has been reported to act as a 5-HT2A receptor antagonist as well.".
- Q7372445 atcPrefix "none".
- Q7372445 casNumber "112192-04-8".
- Q7372445 fdaUniiCode "43227SMS0O".
- Q7372445 iupacName "3-[4-(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)butyl]-1H-indol-5-ol".
- Q7372445 pubchem "219050".
- Q7372445 thumbnail Roxindole.png?width=300.
- Q7372445 wikiPageWikiLink Q11085.
- Q7372445 wikiPageWikiLink Q14866071.
- Q7372445 wikiPageWikiLink Q14891424.
- Q7372445 wikiPageWikiLink Q15335165.
- Q7372445 wikiPageWikiLink Q18022891.
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- Q7372445 wikiPageWikiLink Q208467.
- Q7372445 wikiPageWikiLink Q238509.
- Q7372445 wikiPageWikiLink Q30612.
- Q7372445 wikiPageWikiLink Q389934.
- Q7372445 wikiPageWikiLink Q410943.
- Q7372445 wikiPageWikiLink Q41112.
- Q7372445 wikiPageWikiLink Q417749.
- Q7372445 wikiPageWikiLink Q42844.
- Q7372445 wikiPageWikiLink Q4590759.
- Q7372445 wikiPageWikiLink Q461076.
- Q7372445 wikiPageWikiLink Q4914025.
- Q7372445 wikiPageWikiLink Q62903.
- Q7372445 wikiPageWikiLink Q7139608.
- Q7372445 wikiPageWikiLink Q7335370.
- Q7372445 wikiPageWikiLink Q7455053.
- Q7372445 wikiPageWikiLink Q76560.
- Q7372445 wikiPageWikiLink Q770260.
- Q7372445 wikiPageWikiLink Q8386.
- Q7372445 wikiPageWikiLink Q8546974.
- Q7372445 wikiPageWikiLink Q954831.
- Q7372445 atcPrefix "none".
- Q7372445 casNumber "112192".
- Q7372445 iupacName "3".
- Q7372445 pubchem "219050".
- Q7372445 unii "43227".
- Q7372445 type ChemicalSubstance.
- Q7372445 type Drug.
- Q7372445 type ChemicalObject.
- Q7372445 type Thing.
- Q7372445 type Q8386.
- Q7372445 comment "Roxindole (EMD-49,980) is a dopaminergic and serotonergic drug which was originally developed for the treatment of schizophrenia. In clinical trials its antipsychotic efficacy was only modest but it was unexpectedly found to produce potent and rapid antidepressant and anxiolytic effects. As a result, roxindole was further researched for the treatment of depression instead.".
- Q7372445 label "Roxindole".
- Q7372445 depiction Roxindole.png.