Matches in DBpedia 2016-04 for { <http://wikidata.dbpedia.org/resource/Q7339209> ?p ?o }
Showing triples 1 to 30 of
30
with 100 triples per page.
- Q7339209 subject Q6994655.
- Q7339209 subject Q7403741.
- Q7339209 subject Q7486806.
- Q7339209 subject Q8887197.
- Q7339209 abstract "Ro64-6198 is an nociceptoid drug used in scientific research. It acts as a potent and selective agonist for the nociceptin receptor, also known as the ORL-1 (opiate receptor like-1) receptor, with over 100x selectivity over other opioid receptors. It produces anxiolytic effects in animal studies equivalent to those of benzodiazepine drugs, but has no anticonvulsant effects and does not produce any overt effects on behaviour. However it does impair short-term memory, and counteracts stress-induced anorexia. It also has antitussive effects, and reduces the rewarding and analgesic effects of morphine, although it did not prevent the development of dependence. It has been shown to reduce alcohol self-administration in animals and suppressed relapses in animal models of alcoholism, and ORL-1 agonists may have application in the treatment of alcoholism.Ro64-6198 was able to be recognised as a discriminative stimulus by rats distinct from other opioid receptor ligands, but was not able to produce the conditioned place preference thought to be indicative of addictive potential. Consequently, while the role of ORL-1 receptors in the body is complex and remains poorly understood, Ro64-6198 has demonstrated multiple pharmacological actions and has been very useful in the study of the ORL-1 receptor system, especially in relation to anxiety and anorexia; however, due to poor oral bioavailability, Ro 64-6198 will most likely not be pursued clinically. Studies in primates showed it to have analgesic effects but without producing respiratory depression or reinforcing effects.".
- Q7339209 iupacName "8-[(1S,3aS)-2,3,3a,4,5,6-hexahydro-1H-phenalen-1-yl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one".
- Q7339209 pubchem "9844019".
- Q7339209 thumbnail Ro64-6198_structure.png?width=300.
- Q7339209 wikiPageWikiLink Q14911984.
- Q7339209 wikiPageWikiLink Q1641494.
- Q7339209 wikiPageWikiLink Q173235.
- Q7339209 wikiPageWikiLink Q5159285.
- Q7339209 wikiPageWikiLink Q576618.
- Q7339209 wikiPageWikiLink Q584209.
- Q7339209 wikiPageWikiLink Q62903.
- Q7339209 wikiPageWikiLink Q6994655.
- Q7339209 wikiPageWikiLink Q7403741.
- Q7339209 wikiPageWikiLink Q7486806.
- Q7339209 wikiPageWikiLink Q83871.
- Q7339209 wikiPageWikiLink Q8887197.
- Q7339209 iupacName "8".
- Q7339209 pubchem "9844019".
- Q7339209 type ChemicalSubstance.
- Q7339209 type Drug.
- Q7339209 type ChemicalObject.
- Q7339209 type Thing.
- Q7339209 type Q8386.
- Q7339209 comment "Ro64-6198 is an nociceptoid drug used in scientific research. It acts as a potent and selective agonist for the nociceptin receptor, also known as the ORL-1 (opiate receptor like-1) receptor, with over 100x selectivity over other opioid receptors. It produces anxiolytic effects in animal studies equivalent to those of benzodiazepine drugs, but has no anticonvulsant effects and does not produce any overt effects on behaviour.".
- Q7339209 label "Ro64-6198".
- Q7339209 depiction Ro64-6198_structure.png.