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- Q7318256 subject Q7300121.
- Q7318256 abstract "In the field of drug discovery, reverse pharmacology also known as target-based drug discovery (TDD), a hypothesis is first made that modulation of the activity of a specific protein target will have beneficial therapeutic effects. Screening of chemical libraries of small molecules is then used to identify compounds that bind with high affinity to the target. The hits from these screens are then used as starting points for drug discovery. This method became popular after the sequencing of the human genome which allowed rapid cloning and synthesis of large quantities of purified proteins. This method is the most widely used in drug discovery today. Differently than the classical (forward) pharmacology, with the reverse pharmacology approach in vivo efficacy of identified active (lead) compounds is usually performed in the final drug discovery stages.".
- Q7318256 thumbnail Forward_and_reverse_pharmacology.jpg?width=300.
- Q7318256 wikiPageWikiLink Q1418791.
- Q7318256 wikiPageWikiLink Q192446.
- Q7318256 wikiPageWikiLink Q1988322.
- Q7318256 wikiPageWikiLink Q2963679.
- Q7318256 wikiPageWikiLink Q5128348.
- Q7318256 wikiPageWikiLink Q626251.
- Q7318256 wikiPageWikiLink Q720988.
- Q7318256 wikiPageWikiLink Q7300121.
- Q7318256 wikiPageWikiLink Q903238.
- Q7318256 wikiPageWikiLink Q904407.
- Q7318256 comment "In the field of drug discovery, reverse pharmacology also known as target-based drug discovery (TDD), a hypothesis is first made that modulation of the activity of a specific protein target will have beneficial therapeutic effects. Screening of chemical libraries of small molecules is then used to identify compounds that bind with high affinity to the target. The hits from these screens are then used as starting points for drug discovery.".
- Q7318256 label "Reverse pharmacology".
- Q7318256 depiction Forward_and_reverse_pharmacology.jpg.