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- Q7294624 subject Q8802898.
- Q7294624 subject Q9089708.
- Q7294624 subject Q9531303.
- Q7294624 abstract "RasGEF domain is domain found in the CDC25 family of guanine nucleotide exchange factors for Ras-like small GTPases.Ras proteins are membrane-associated molecular switches that bind GTP and GDP and slowly hydrolyze GTP to GDP. The balance between the GTP bound (active) and GDP bound (inactive) states is regulated by the opposite action of proteins activating the GTPase activity and that of proteins which promote the loss of bound GDP and the uptake of fresh GTP. The latter proteins are known as guanine-nucleotide dissociation stimulators (GDSs) (or also as guanine-nucleotide releasing (or exchange) factors (GRFs)). Proteins that act as GDS can be classified into at least two families, on the basis of sequence similarities, the CDC24 family (see IPR001331) and this CDC25 (RasGEF) family.The size of the proteins of the CDC25 family range from 309 residues (LTE1) to 1596 residues (sos). The sequence similarity shared by all these proteins is limited to a region of about 250 amino acids generally located in their C-terminal section (currently the only exceptions are sos and ralGDS where this domain makes up the central part of the protein). This domain has been shown, in CDC25 an SCD25, to be essential for the activity of these proteins.".
- Q7294624 symbol "RasGEF".
- Q7294624 thumbnail PDB_1bkd_EBI.jpg?width=300.
- Q7294624 wikiPageWikiLink Q13394823.
- Q7294624 wikiPageWikiLink Q14908123.
- Q7294624 wikiPageWikiLink Q18026478.
- Q7294624 wikiPageWikiLink Q18030988.
- Q7294624 wikiPageWikiLink Q18031027.
- Q7294624 wikiPageWikiLink Q18031049.
- Q7294624 wikiPageWikiLink Q18031050.
- Q7294624 wikiPageWikiLink Q18034532.
- Q7294624 wikiPageWikiLink Q18034589.
- Q7294624 wikiPageWikiLink Q18034659.
- Q7294624 wikiPageWikiLink Q18035049.
- Q7294624 wikiPageWikiLink Q18035148.
- Q7294624 wikiPageWikiLink Q18035363.
- Q7294624 wikiPageWikiLink Q18036099.
- Q7294624 wikiPageWikiLink Q18037684.
- Q7294624 wikiPageWikiLink Q18040087.
- Q7294624 wikiPageWikiLink Q18040541.
- Q7294624 wikiPageWikiLink Q18049173.
- Q7294624 wikiPageWikiLink Q18053460.
- Q7294624 wikiPageWikiLink Q417841.
- Q7294624 wikiPageWikiLink Q7294687.
- Q7294624 wikiPageWikiLink Q7560667.
- Q7294624 wikiPageWikiLink Q769143.
- Q7294624 wikiPageWikiLink Q8802898.
- Q7294624 wikiPageWikiLink Q901088.
- Q7294624 wikiPageWikiLink Q9089708.
- Q7294624 wikiPageWikiLink Q9531303.
- Q7294624 symbol "RasGEF".
- Q7294624 type Biomolecule.
- Q7294624 type Protein.
- Q7294624 type Thing.
- Q7294624 type Q206229.
- Q7294624 type Q8054.
- Q7294624 comment "RasGEF domain is domain found in the CDC25 family of guanine nucleotide exchange factors for Ras-like small GTPases.Ras proteins are membrane-associated molecular switches that bind GTP and GDP and slowly hydrolyze GTP to GDP. The balance between the GTP bound (active) and GDP bound (inactive) states is regulated by the opposite action of proteins activating the GTPase activity and that of proteins which promote the loss of bound GDP and the uptake of fresh GTP.".
- Q7294624 label "RasGEF domain".
- Q7294624 depiction PDB_1bkd_EBI.jpg.