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- Q7259621 subject Q7775055.
- Q7259621 abstract "Pulsatile insulin, sometimes called metabolic activation therapy, or cellular activation therapy describes in a literal sense the intravenous injection of insulin in pulses versus continuous infusions. Injection of insulin in pulses mimics the physiological secretions of insulin by the pancreas into the portal vein which then drains into the liver. In healthy, non-diabetic individuals, pancreatic secretions of insulin correspond to the intake of food. The pancreas will secrete variable amounts of insulin based upon the amount of food consumed (basically speaking, the more food that is consumed, the more insulin the pancreas will secrete) among other factors. The majority of available experimental evidence suggests a more potent hypoglycemic effect of pulsatile insulin in comparison to continuous insulin infusion. Continuous exposure to insulin and glucagon is known to decrease the hormones’ metabolic effectiveness on glucose production in humans due to the body developing an increased tolerance to the hormones. Down-regulation at the cellular level may partially explain the decreased action of steady-state levels of insulin, while pulsatile hormone secretion may allow recovery of receptor affinity and numbers for insulin. Intermittent intravenous insulin administration with peaks of insulin concentrations may enhance suppression of gluconeogenesis and reduce hepatic glucose production.".
- Q7259621 wikiPageExternalLink trinahealthwestla.com.
- Q7259621 wikiPageExternalLink diabetes-treatment.
- Q7259621 wikiPageWikiLink Q100.
- Q7259621 wikiPageWikiLink Q1057.
- Q7259621 wikiPageWikiLink Q11364.
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- Q7259621 wikiPageWikiLink Q771.
- Q7259621 wikiPageWikiLink Q7775055.
- Q7259621 wikiPageWikiLink Q7868.
- Q7259621 wikiPageWikiLink Q8047.
- Q7259621 wikiPageWikiLink Q827450.
- Q7259621 wikiPageWikiLink Q900970.
- Q7259621 wikiPageWikiLink Q9368.
- Q7259621 wikiPageWikiLink Q9618.
- Q7259621 comment "Pulsatile insulin, sometimes called metabolic activation therapy, or cellular activation therapy describes in a literal sense the intravenous injection of insulin in pulses versus continuous infusions. Injection of insulin in pulses mimics the physiological secretions of insulin by the pancreas into the portal vein which then drains into the liver. In healthy, non-diabetic individuals, pancreatic secretions of insulin correspond to the intake of food.".
- Q7259621 label "Pulsatile insulin".