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- Q7226511 subject Q8802898.
- Q7226511 abstract "In molecular biology, the polyketide synthesis cyclase family of proteins includes a number of cyclases involved in polyketide synthesis in a number of actinobacterial species.Aromatic polyketides are assembled by a type II (iterative) polyketide synthase in bacteria. Iterative type II polyketide synthases produce polyketide chains of variable but defined length from a specific starter unit and a number of extender units. They also specify the initial regiospecific folding and cyclisation pattern of nascent polyketides either through the action of a cyclase (CYC) subunit or through the combined action of site-specific ketoreductase and CYC subunits. Additional CYCs and other modifications may be necessary to produce linear aromatic polyketides. The Tetracenomycin polyketide synthesis protein, tcmI, from Streptomyces glaucescens catalyses an aromatic rearrangement in the biosynthetic pathaway of tetracenomycin C from Streptomyces coelicolor. The protein is a homodimer where each subunit forms a beta-alpha-beta fold belonging to the ferrodoxin fold superfamily. Four strands of antiparallel sheets and a layer of alpha helices create a cavity which was proposed to be the active site. This structure shows strong topological similarity to a polyketide monoxygenase from Streptomyces coelicolor which functions in the actinorhodin biosynthesic pathway. It was suggested, therefore, that this fold is well suited to serve as a framework for rearrangements and chemical modification of polyaromatic substrates.".
- Q7226511 symbol "Cyclase_polyket".
- Q7226511 thumbnail PDB_1tuw_EBI.jpg?width=300.
- Q7226511 wikiPageWikiLink Q10876.
- Q7226511 wikiPageWikiLink Q130914.
- Q7226511 wikiPageWikiLink Q15712714.
- Q7226511 wikiPageWikiLink Q230731.
- Q7226511 wikiPageWikiLink Q2355919.
- Q7226511 wikiPageWikiLink Q283399.
- Q7226511 wikiPageWikiLink Q283449.
- Q7226511 wikiPageWikiLink Q415215.
- Q7226511 wikiPageWikiLink Q423026.
- Q7226511 wikiPageWikiLink Q4369963.
- Q7226511 wikiPageWikiLink Q4676996.
- Q7226511 wikiPageWikiLink Q516751.
- Q7226511 wikiPageWikiLink Q5198121.
- Q7226511 wikiPageWikiLink Q581027.
- Q7226511 wikiPageWikiLink Q6589727.
- Q7226511 wikiPageWikiLink Q7432.
- Q7226511 wikiPageWikiLink Q8054.
- Q7226511 wikiPageWikiLink Q82264.
- Q7226511 wikiPageWikiLink Q847556.
- Q7226511 wikiPageWikiLink Q8802898.
- Q7226511 wikiPageWikiLink Q899781.
- Q7226511 symbol "Cyclase_polyket".
- Q7226511 type Biomolecule.
- Q7226511 type Protein.
- Q7226511 type Thing.
- Q7226511 type Q206229.
- Q7226511 type Q8054.
- Q7226511 comment "In molecular biology, the polyketide synthesis cyclase family of proteins includes a number of cyclases involved in polyketide synthesis in a number of actinobacterial species.Aromatic polyketides are assembled by a type II (iterative) polyketide synthase in bacteria. Iterative type II polyketide synthases produce polyketide chains of variable but defined length from a specific starter unit and a number of extender units.".
- Q7226511 label "Polyketide synthesis cyclase family".
- Q7226511 depiction PDB_1tuw_EBI.jpg.