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- Q7116906 subject Q7204727.
- Q7116906 abstract "The positive transcription elongation factor, P-TEFb, plays an essential role in the regulation of transcription by RNA polymerase II (Pol II) in eukaryotes. Immediately following initiation Pol II becomes trapped in promoter proximal paused positions on the majority of human genes (Figure 1). P-TEFb is a cyclin dependent kinase that can phosphorylate the DRB sensitivity inducing factor (DSIF) and negative elongation factor (NELF), as well as the carboxyl terminal domain of the large subunit of Pol II and this causes the transition into productive elongation leading to the synthesis of mRNAs. P-TEFb is regulated in part by a reversible association with the 7SK snRNP. Treatment of cells with the P-TEFb inhibitors DRB or flavopidirol leads to loss of mRNA production and ultimately cell death.".
- Q7116906 thumbnail RNA_polymerase_II_elongation_control.jpg?width=300.
- Q7116906 wikiPageWikiLink Q15314942.
- Q7116906 wikiPageWikiLink Q15787.
- Q7116906 wikiPageWikiLink Q18035530.
- Q7116906 wikiPageWikiLink Q18037206.
- Q7116906 wikiPageWikiLink Q18049593.
- Q7116906 wikiPageWikiLink Q18049613.
- Q7116906 wikiPageWikiLink Q1829843.
- Q7116906 wikiPageWikiLink Q188928.
- Q7116906 wikiPageWikiLink Q3981457.
- Q7116906 wikiPageWikiLink Q4063441.
- Q7116906 wikiPageWikiLink Q425326.
- Q7116906 wikiPageWikiLink Q46292.
- Q7116906 wikiPageWikiLink Q4639543.
- Q7116906 wikiPageWikiLink Q5206143.
- Q7116906 wikiPageWikiLink Q5747236.
- Q7116906 wikiPageWikiLink Q6987209.
- Q7116906 wikiPageWikiLink Q7204727.
- Q7116906 comment "The positive transcription elongation factor, P-TEFb, plays an essential role in the regulation of transcription by RNA polymerase II (Pol II) in eukaryotes. Immediately following initiation Pol II becomes trapped in promoter proximal paused positions on the majority of human genes (Figure 1).".
- Q7116906 label "P-TEFb".
- Q7116906 depiction RNA_polymerase_II_elongation_control.jpg.