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- Q7101736 subject Q8334258.
- Q7101736 subject Q8341873.
- Q7101736 abstract "Org 27569 is a drug which acts as a potent and selective allosteric modulator of the cannabinoid CB1 receptor. Studies in vitro suggest that it binds to a regulatory site on the CB1 receptor target, causing a conformational change that increases the binding affinity of CB1 agonists such as CP 55,940, while decreasing the binding affinity of CB1 antagonists or inverse agonists such as rimonabant. However while Org 27569 increases the ability of CB1 agonists to bind to the receptor, it decreases their efficacy at stimulating second messenger signalling once bound, and so in practice behaves as an insurmountable antagonist of CB1 receptor function.".
- Q7101736 casNumber "868273-06-7".
- Q7101736 iupacName "5-chloro-3-ethyl-1H-indole-2-carboxylic acid[2-(4-piperidin-1-yl-phenyl)ethyl]amide".
- Q7101736 pubchem "44828492".
- Q7101736 thumbnail Org27569_structure.png?width=300.
- Q7101736 wikiPageWikiLink Q208467.
- Q7101736 wikiPageWikiLink Q21163314.
- Q7101736 wikiPageWikiLink Q2649417.
- Q7101736 wikiPageWikiLink Q410943.
- Q7101736 wikiPageWikiLink Q412529.
- Q7101736 wikiPageWikiLink Q422936.
- Q7101736 wikiPageWikiLink Q5013768.
- Q7101736 wikiPageWikiLink Q8334258.
- Q7101736 wikiPageWikiLink Q8341873.
- Q7101736 wikiPageWikiLink Q898254.
- Q7101736 wikiPageWikiLink Q899814.
- Q7101736 casNumber "868273".
- Q7101736 iupacName "5".
- Q7101736 pubchem "44828492".
- Q7101736 type ChemicalSubstance.
- Q7101736 type Drug.
- Q7101736 type ChemicalObject.
- Q7101736 type Thing.
- Q7101736 type Q8386.
- Q7101736 comment "Org 27569 is a drug which acts as a potent and selective allosteric modulator of the cannabinoid CB1 receptor. Studies in vitro suggest that it binds to a regulatory site on the CB1 receptor target, causing a conformational change that increases the binding affinity of CB1 agonists such as CP 55,940, while decreasing the binding affinity of CB1 antagonists or inverse agonists such as rimonabant.".
- Q7101736 label "Org 27569".
- Q7101736 depiction Org27569_structure.png.