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- Q7053207 subject Q6938881.
- Q7053207 subject Q8702226.
- Q7053207 subject Q8758634.
- Q7053207 subject Q8788410.
- Q7053207 subject Q8878420.
- Q7053207 subject Q9134654.
- Q7053207 abstract "Norpropoxyphene is a major metabolite of the opioid analgesic drug dextropropoxyphene, and is responsible for many of the side effects associated with use of this drug, especially the unusual toxicity seen during dextropropoxyphene overdose. It has weaker analgesic effects than dextropropoxyphene itself, but is a relatively potent pro-convulsant and blocker of sodium and potassium channels, particularly in heart tissue, which produces prolonged intracardiac conduction time and can lead to heart failure following even relatively minor overdoses. The toxicity of this metabolite makes dextropropoxyphene up to 10 times more likely to cause death following overdose compared to other similar mild opioid analgesics, and has led to dextropropoxyphene being withdrawn from the market in some countries.Because norpropoxyphene has a long half-life in the body of up to 36 hours (compared to around 6–12 hours for dextropropoxyphene), it can accumulate in tissues during chronic use of dextropropoxyphene-containing medications, especially in people whose excretion of drugs is slower than normal such as young children, the elderly, and individuals with reduced kidney or liver function, and so side effects including serious adverse events are more common in these groups and use of dextropropoxyphene should be avoided where possible.".
- Q7053207 iupacName "[(2R,3R)-3-methyl-4-(methylamino)-1,2-di(phenyl)butan-2-yl]propanoate".
- Q7053207 thumbnail Norpropoxyphene.png?width=300.
- Q7053207 wikiPageWikiLink Q173235.
- Q7053207 wikiPageWikiLink Q2268608.
- Q7053207 wikiPageWikiLink Q3505252.
- Q7053207 wikiPageWikiLink Q423778.
- Q7053207 wikiPageWikiLink Q424960.
- Q7053207 wikiPageWikiLink Q427523.
- Q7053207 wikiPageWikiLink Q5166679.
- Q7053207 wikiPageWikiLink Q62536.
- Q7053207 wikiPageWikiLink Q6938881.
- Q7053207 wikiPageWikiLink Q8702226.
- Q7053207 wikiPageWikiLink Q8758634.
- Q7053207 wikiPageWikiLink Q8788410.
- Q7053207 wikiPageWikiLink Q8878420.
- Q7053207 wikiPageWikiLink Q9134654.
- Q7053207 iupacname "[-3-methyl-4--1,2-dibutan-2-yl] propanoate".
- Q7053207 type ChemicalCompound.
- Q7053207 type ChemicalSubstance.
- Q7053207 type ChemicalObject.
- Q7053207 type Thing.
- Q7053207 type Q11173.
- Q7053207 comment "Norpropoxyphene is a major metabolite of the opioid analgesic drug dextropropoxyphene, and is responsible for many of the side effects associated with use of this drug, especially the unusual toxicity seen during dextropropoxyphene overdose.".
- Q7053207 label "Norpropoxyphene".
- Q7053207 depiction Norpropoxyphene.png.