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- Q6808812 subject Q8590801.
- Q6808812 subject Q9532257.
- Q6808812 abstract "Megaphone is a cytotoxic neolignan obtained from Aniba megaphylla, a flowering plant of Laurel family which gave the compound its name. Megaphone has also been prepared synthetically.Studies carried out in the 1960s demonstrated that an alcoholic extract of the ground root of Aniba megaphylla inhibited, in vitro, growth of cells derived from human carcinoma of the nasopharynx. In 1978, the active components of the extract were isolated using silica gel chromatography, characterized and named as megaphone (C22H30O6, solid), megaphone acetate (C24H32O7, oily liquid) and megaphyllone acetate (C23H28O7, oily liquid). For comparison, megaphone acetate was also produced synthetically by reacting megaphone with acetic anhydride at 50 °C for 6 hours. Stirring an alcoholic solution of megaphone (megaphone acetate), with added palladium catalyst, in hydrogen atmosphere, followed by evaporation of the solvent yields tetrahydromegaphone (tetrahydromegaphone acetate) as an oil. Millimeter-sized crystals of megaphone can be grown from an ether-chloroform solution. They have monoclinic symmetry with space group P21, lattice constants a = 0.8757 nm, b = 1.1942 nm and c = 1.0177 nm and two formula units per unit cell. Megaphone and megaphone acetate molecules are chiral and the reported extraction and synthesis procedures yielded their racemic mixtures. Megaphone acetate was also isolated from the root of Endlicheria dysodantha, another plant of Laurel family, using chromatography of ethanolic solution. It showed inhibitory activity against cells of crown gall tumor and human lung, breast and colon carcinomas.".
- Q6808812 iupacName "6-[1-hydroxy-1-(3,4,5-trimethoxyphenyl)propan-2-yl]-4-methoxy-6-prop-2-enylcyclohex-2-en-1-one".
- Q6808812 thumbnail Megaphone_chemical_structure.png?width=300.
- Q6808812 wikiPageWikiLink Q103230.
- Q6808812 wikiPageWikiLink Q1437643.
- Q6808812 wikiPageWikiLink Q170050.
- Q6808812 wikiPageWikiLink Q172275.
- Q6808812 wikiPageWikiLink Q174778.
- Q6808812 wikiPageWikiLink Q212527.
- Q6808812 wikiPageWikiLink Q214514.
- Q6808812 wikiPageWikiLink Q246181.
- Q6808812 wikiPageWikiLink Q25314.
- Q6808812 wikiPageWikiLink Q26538.
- Q6808812 wikiPageWikiLink Q308976.
- Q6808812 wikiPageWikiLink Q33525.
- Q6808812 wikiPageWikiLink Q407775.
- Q6808812 wikiPageWikiLink Q424634.
- Q6808812 wikiPageWikiLink Q467717.
- Q6808812 wikiPageWikiLink Q4764446.
- Q6808812 wikiPageWikiLink Q8590801.
- Q6808812 wikiPageWikiLink Q895901.
- Q6808812 wikiPageWikiLink Q899033.
- Q6808812 wikiPageWikiLink Q9532257.
- Q6808812 iupacname "6".
- Q6808812 name "Megaphone".
- Q6808812 type ChemicalCompound.
- Q6808812 type ChemicalSubstance.
- Q6808812 type ChemicalObject.
- Q6808812 type Thing.
- Q6808812 type Q11173.
- Q6808812 comment "Megaphone is a cytotoxic neolignan obtained from Aniba megaphylla, a flowering plant of Laurel family which gave the compound its name. Megaphone has also been prepared synthetically.Studies carried out in the 1960s demonstrated that an alcoholic extract of the ground root of Aniba megaphylla inhibited, in vitro, growth of cells derived from human carcinoma of the nasopharynx.".
- Q6808812 label "Megaphone (molecule)".
- Q6808812 depiction Megaphone_chemical_structure.png.
- Q6808812 name "Megaphone".