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- Q6760431 subject Q7486344.
- Q6760431 abstract "Marginal zone B cells are noncirculating mature B cells that segregate anatomically into the marginal zone (MZ) of the spleen. This region contains multiple subtypes of macrophages, dendritic cells, and the MZ B cells; it is not fully formed until 2 to 3 weeks after birth in rodents and 1 to 2 years in humans. The MZ B cells within this region typically express high levels of sIgM, CD21, CD1, CD9 with low to negligible levels of sIgD, CD23, CD5, and CD11b that help to distinguish them phenotypically from follicular (FO) B cells and B1 B cells. In humans the splenic marginal zone B cells have evidence of somatic hypermutation in their immunoglobulin genes, indicating that they have been generated through a germinal centre reaction to become memory cells. Similar to B1 B cells, MZ B cells can be rapidly recruited into the early adaptive immune responses in a T cell independent manner. The MZ B cells are especially well positioned as a first line of defense against systemic blood-borne antigens that enter the circulation and become trapped in the spleen. It is believed they are especially reactive to bacterial cell wall components and self-antigens which are the products of aging. MZ B cells also display a lower activation threshold than their FO B cell counterparts with heightened propensity for plasma cell differentiation that contributes further to the accelerated primary antibody response.In specimens where the tyrosine kinase for Pyk-2 has been knocked-out, marginal zone B-cells will fail to develop while B-1 cells will still be present.MZ B-cells are the only B-cells dependent on NOTCH2 signaling for proliferation.".
- Q6760431 wikiPageWikiLink Q14876567.
- Q6760431 wikiPageWikiLink Q14905324.
- Q6760431 wikiPageWikiLink Q14905337.
- Q6760431 wikiPageWikiLink Q14912836.
- Q6760431 wikiPageWikiLink Q15315271.
- Q6760431 wikiPageWikiLink Q17927283.
- Q6760431 wikiPageWikiLink Q18030183.
- Q6760431 wikiPageWikiLink Q184204.
- Q6760431 wikiPageWikiLink Q188930.
- Q6760431 wikiPageWikiLink Q193529.
- Q6760431 wikiPageWikiLink Q2248081.
- Q6760431 wikiPageWikiLink Q250694.
- Q6760431 wikiPageWikiLink Q3832893.
- Q6760431 wikiPageWikiLink Q506253.
- Q6760431 wikiPageWikiLink Q5464649.
- Q6760431 wikiPageWikiLink Q6760434.
- Q6760431 wikiPageWikiLink Q7486344.
- Q6760431 wikiPageWikiLink Q79447.
- Q6760431 wikiPageWikiLink Q79451.
- Q6760431 wikiPageWikiLink Q9371.
- Q6760431 comment "Marginal zone B cells are noncirculating mature B cells that segregate anatomically into the marginal zone (MZ) of the spleen. This region contains multiple subtypes of macrophages, dendritic cells, and the MZ B cells; it is not fully formed until 2 to 3 weeks after birth in rodents and 1 to 2 years in humans.".
- Q6760431 label "Marginal zone B-cell".