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- Q6717000 subject Q7214357.
- Q6717000 abstract "Template:SeealsoMODY 1 is a form of maturity onset diabetes of the young.MODY 1 is due to a loss-of-function mutation in the HNF4A gene on chromosome 20. This gene codes for HNF4-α protein also known as transcription factor 14 (TCF14). HNF4α controls function of HNF1α (see MODY 3; HNF1A) and perhaps HNF1β (MODY 5) as well. This transcription network plays a role in the early development of the pancreas, liver, and intestines. In the pancreas these genes influence expression of, among others, the genes for insulin, the principal glucose transporter (GLUT2), and several proteins involved in glucose and mitochondrial metabolism. Although pancreatic beta cells produce adequate insulin in infancy, the capacity for insulin production declines thereafter. Diabetes (persistent hyperglycemia) typically develops by early adult years, but may not appear until later decades. The degree of insulin deficiency is slowly progressive. Many patients with MODY 1 are treated with sulfonylureas for years before insulin is required.Liver effects are subtle and not clinically significant. Many people with this condition have low levels of triglycerides, lipoprotein(a), apolipoproteins AII and CIII.Mutations in the alternative promoter of HNF4A are linked to development of type 2 diabetes.".
- Q6717000 wikiPageWikiLink Q18028636.
- Q6717000 wikiPageWikiLink Q18031525.
- Q6717000 wikiPageWikiLink Q18031867.
- Q6717000 wikiPageWikiLink Q18031868.
- Q6717000 wikiPageWikiLink Q186319.
- Q6717000 wikiPageWikiLink Q3064192.
- Q6717000 wikiPageWikiLink Q407384.
- Q6717000 wikiPageWikiLink Q416890.
- Q6717000 wikiPageWikiLink Q420277.
- Q6717000 wikiPageWikiLink Q6431240.
- Q6717000 wikiPageWikiLink Q663041.
- Q6717000 wikiPageWikiLink Q666752.
- Q6717000 wikiPageWikiLink Q6717003.
- Q6717000 wikiPageWikiLink Q6717006.
- Q6717000 wikiPageWikiLink Q7214357.
- Q6717000 wikiPageWikiLink Q9368.
- Q6717000 type Thing.
- Q6717000 comment "Template:SeealsoMODY 1 is a form of maturity onset diabetes of the young.MODY 1 is due to a loss-of-function mutation in the HNF4A gene on chromosome 20. This gene codes for HNF4-α protein also known as transcription factor 14 (TCF14). HNF4α controls function of HNF1α (see MODY 3; HNF1A) and perhaps HNF1β (MODY 5) as well. This transcription network plays a role in the early development of the pancreas, liver, and intestines.".
- Q6717000 label "MODY 1".
- Q6717000 seeAlso Q18027054.