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- Q6680282 subject Q18924462.
- Q6680282 subject Q7297892.
- Q6680282 subject Q8727262.
- Q6680282 subject Q8872471.
- Q6680282 abstract "Loreclezole is a sedative and an anticonvulsant which acts as a GABAA receptor positive allosteric modulator. The binding site of loreclezole has been shown experimentally to be shared by valerenic acid, an extract of the root of the valerian plant. Structurally, loreclezole is a triazole derivative. In animal seizure models, loreclezole is protective against pentylenetetrazol seizures but is less active in the maximal electroshock test. In addition, at low, nontoxic doses, the drug has anti-absence activity in a genetic model of generalized absence epilepsy. Consequently, loreclezole has a profile of activity similar to that of benzodiazepines. A potential benzodiazepine-like interaction with GABA receptors is suggested by the observation that the anticonvulsant effects of loreclezole can be reversed by benzodiazepine receptor inverse agonists. The benzodiazepine antagonist flumazenil, however, fails to alter the anticonvulsant activity of loreclezole, indicating that loreclezole is not a benzodiazepine receptor agonist. Using native rat and cloned human GABA-A receptors, loreclezole strongly potentiated GABA-activated chloride current. However, activity of the drug did not require the presence of the γ-subunit and was not blocked by flumazenil, confirming that loreclezole does not interact with the benzodiazepine recognition site.".
- Q6680282 atcPrefix "none".
- Q6680282 casNumber "117857-45-1".
- Q6680282 fdaUniiCode "6DJ32STZ5W".
- Q6680282 iupacName "1-[(Z)-2-chloro-2-(2,4-dichlorophenyl)vinyl]-1H-1,2,4-triazole".
- Q6680282 pubchem "3034012".
- Q6680282 thumbnail Loreclezole.svg?width=300.
- Q6680282 wikiPageWikiLink Q157819.
- Q6680282 wikiPageWikiLink Q18924462.
- Q6680282 wikiPageWikiLink Q2649417.
- Q6680282 wikiPageWikiLink Q576618.
- Q6680282 wikiPageWikiLink Q60147.
- Q6680282 wikiPageWikiLink Q7297892.
- Q6680282 wikiPageWikiLink Q75850.
- Q6680282 wikiPageWikiLink Q83871.
- Q6680282 wikiPageWikiLink Q847705.
- Q6680282 wikiPageWikiLink Q8727262.
- Q6680282 wikiPageWikiLink Q8872471.
- Q6680282 atcPrefix "none".
- Q6680282 casNumber "117857".
- Q6680282 iupacName "1".
- Q6680282 pubchem "3034012".
- Q6680282 unii "6".
- Q6680282 type ChemicalSubstance.
- Q6680282 type Drug.
- Q6680282 type ChemicalObject.
- Q6680282 type Thing.
- Q6680282 type Q8386.
- Q6680282 comment "Loreclezole is a sedative and an anticonvulsant which acts as a GABAA receptor positive allosteric modulator. The binding site of loreclezole has been shown experimentally to be shared by valerenic acid, an extract of the root of the valerian plant. Structurally, loreclezole is a triazole derivative. In animal seizure models, loreclezole is protective against pentylenetetrazol seizures but is less active in the maximal electroshock test.".
- Q6680282 label "Loreclezole".
- Q6680282 depiction Loreclezole.svg.