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- Q6619630 subject Q7486806.
- Q6619630 abstract "Vince lactam is the commercial name given to the bicyclic molecule γ-lactam 2-azabicyclo[2.2.1]hept-5-en-3-one. This lactam is a versatile chemical intermediate used in organic and medicinal chemistry. It is used as a synthetic precursor for three drugs (approved or in clinical trials). It is named after Robert Vince who has used the structural features of this molecule for the preparation of carbocyclic nucleosides. Vince's work with this lactam eventually led to his synthesis of abacavir.Vince lactam has been extensively used for the preparation of various carbocyclic nucleosides with medicinal applications in mind, including carbocyclic puromycin (I), carbocyclic Ara-A (II), carbovir (III) and guanine as well as azaguanine carbocyclic derivatives (IV)Prepared Carbocyclic Nucleoside Analogs by Using Vince LactamVince lactam is also an intermediate in the synthesis of various nucleoside analogs such as difluoro guanosine derivatives (V), carbocyclic oxanosine and related derivatives (VI), and precursors for azidocarbonucleosides (VII). The lactam has found several applications in targeting an array of different diseased conditions by providing various non-nucleoside therapeutic molecules as well. Some well known examples include scaffolds for the preparation of glycosidase inhibitors (VIII) and GABA-AT inhibitors (IX).Prepared Nucleoside and non-nucleoside molecules with applications by using Vince Lactam".
- Q6619630 iupacName "2-Azabicyclo[2.2.1]hept-5-en-3-one".
- Q6619630 thumbnail Vince_lactam.png?width=300.
- Q6619630 wikiPageWikiLink Q19981105.
- Q6619630 wikiPageWikiLink Q225972.
- Q6619630 wikiPageWikiLink Q251124.
- Q6619630 wikiPageWikiLink Q28734.
- Q6619630 wikiPageWikiLink Q304330.
- Q6619630 wikiPageWikiLink Q7486806.
- Q6619630 iupacname "2".
- Q6619630 type ChemicalCompound.
- Q6619630 type ChemicalSubstance.
- Q6619630 type ChemicalObject.
- Q6619630 type Thing.
- Q6619630 type Q11173.
- Q6619630 comment "Vince lactam is the commercial name given to the bicyclic molecule γ-lactam 2-azabicyclo[2.2.1]hept-5-en-3-one. This lactam is a versatile chemical intermediate used in organic and medicinal chemistry. It is used as a synthetic precursor for three drugs (approved or in clinical trials). It is named after Robert Vince who has used the structural features of this molecule for the preparation of carbocyclic nucleosides.".
- Q6619630 label "Vince lactam".
- Q6619630 depiction Vince_lactam.png.