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- Q657362 subject Q15267336.
- Q657362 subject Q4926419.
- Q657362 subject Q8266666.
- Q657362 subject Q8638071.
- Q657362 abstract "A reeler is a mouse mutant, so named because of its characteristic "reeling" gait. This is caused by profound hypoplasia of the mouse's cerebellum, in which the normal cerebellar folia are missing. The mutation is autosomal and recessive.Cortical neurons are generated normally but are abnormally placed, resulting in disorganization of cortical laminar layers in the CNS. The reason is the lack of Reelin, an extracellular matrix glycoprotein, which during the corticogenesis is secreted mainly by the Cajal-Retzius cells.In the reeler neocortex, cortical plate neurons are aligned in a practically inverted fashion (‘‘outside-in’’). In the ventricular zone of the cortex fewer neurons have been found to have radial glial processes. In the dentate gyrus of hippocampus, no characteristic radial glial scaffold is formed and no compact granule cell layer is established. Therefore, the reeler mouse presents a good model in which to investigate the mechanisms of establishment of the precise neuronal network during development.".
- Q657362 thumbnail Reeler_lamination.png?width=300.
- Q657362 wikiPageExternalLink march.html.
- Q657362 wikiPageWikiLink Q104053.
- Q657362 wikiPageWikiLink Q10676833.
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- Q657362 wikiPageWikiLink Q15267336.
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- Q657362 wikiPageWikiLink Q4926419.
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- Q657362 wikiPageWikiLink Q8266666.
- Q657362 wikiPageWikiLink Q83310.
- Q657362 wikiPageWikiLink Q8638071.
- Q657362 comment "A reeler is a mouse mutant, so named because of its characteristic "reeling" gait. This is caused by profound hypoplasia of the mouse's cerebellum, in which the normal cerebellar folia are missing. The mutation is autosomal and recessive.Cortical neurons are generated normally but are abnormally placed, resulting in disorganization of cortical laminar layers in the CNS.".
- Q657362 label "Reeler".
- Q657362 depiction Reeler_lamination.png.