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- Q637997 subject Q7061790.
- Q637997 subject Q7214341.
- Q637997 abstract "High endothelial venules (HEV) are specialized post-capillary venous swellings characterized by plump endothelial cells as opposed to the usual thinner endothelial cells found in regular venules. HEVs enable lymphocytes circulating in the blood to directly enter a lymph node (by crossing through the HEV).In humans, HEVs are found in all secondary lymphoid organs (with the exception of spleen, where blood exits through open arterioles and enters the red pulp), including hundreds of lymph nodes dispersed in the body, tonsils and adenoids in the pharynx, Peyer's patches (PIs) in the small intestine, appendix, and small aggregates of lymphoid tissue in the stomach and large intestine. In contrast to the endothelial cells from other vessels, the high endothelial cells of HEVs have a distinctive appearance, consisting of a cuboidal morphology and with various receptors to interact with leukocytes (express specialized ligands for lymphocytes and are able to support high levels of lymphocyte extravasation). HEVs enable naïve lymphocytes to move in and out of the lymph nodes from the circulatory system. HEV cells express addressins, which are specific adhesion molecules that attach to the L-selectins on lymphocytes and anchor them to the HEV wall in preparation for crossing the endothelium.The endothelial cells of HEVs have a 'plump' appearance different from the flat morphology of endothelial cells that line other vessels, and are therefore called high endothelial cells by reference to their thickness. Another characteristic of HEVs, revealed by light-microscopic examination, is the presence of a large number of lymphocytes within their walls. This illustrates the function of HEVs in lymphocyte recruitment, and explains why these vessels were implicated in lymphocyte traffic from the time of their initial description.".
- Q637997 wikiPageWikiLink Q103142.
- Q637997 wikiPageWikiLink Q1047791.
- Q637997 wikiPageWikiLink Q1076345.
- Q637997 wikiPageWikiLink Q1093858.
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- Q637997 wikiPageWikiLink Q42395.
- Q637997 wikiPageWikiLink Q5009764.
- Q637997 wikiPageWikiLink Q506253.
- Q637997 wikiPageWikiLink Q552087.
- Q637997 wikiPageWikiLink Q599966.
- Q637997 wikiPageWikiLink Q7061790.
- Q637997 wikiPageWikiLink Q712604.
- Q637997 wikiPageWikiLink Q715347.
- Q637997 wikiPageWikiLink Q7214341.
- Q637997 wikiPageWikiLink Q7873.
- Q637997 wikiPageWikiLink Q854346.
- Q637997 wikiPageWikiLink Q9371.
- Q637997 comment "High endothelial venules (HEV) are specialized post-capillary venous swellings characterized by plump endothelial cells as opposed to the usual thinner endothelial cells found in regular venules.".
- Q637997 label "High endothelial venules".