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- Q6125539 subject Q7469560.
- Q6125539 subject Q8660039.
- Q6125539 abstract "Reversible inhibitors of monoamine oxidase A (RIMAs) are a class of drugs which selectively and reversibly inhibit the enzyme monoamine oxidase A (MAO-A). They are used clinically in the treatment of depression and dysthymia, though they have not gained widespread market share in the United States. Because of their reversibility and selectivity, RIMAs are safer than the older monoamine oxidase inhibitors (MAOIs) like phenelzine and tranylcypromine.RIMAs are displaced from MAO-A in the presence of tyramine, rather than inhibiting its breakdown in the liver as general MAOIs do. Additionally, MAO-B remains free and continues to metabolize tyramine in the stomach, although this is less significant than the liver action. Thus, RIMAs are unlikely to elicit tyramine-mediated hypertensive crisis, and a special diet does not need to be so strictly adhered to.While safer than general MAOIs, RIMAs still have highly dangerous and sometimes fatal interactions with many common drugs; in particular, they can cause serotonin syndrome or hypertensive crisis when combined with almost any antidepressant or stimulant, common migraine medications, certain herbs, or even most cold medicines (including decongestants, antihistamines, and cough syrup).".
- Q6125539 thumbnail Moclobemide.svg?width=300.
- Q6125539 wikiPageWikiLink Q12140.
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- Q6125539 wikiPageWikiLink Q7469560.
- Q6125539 wikiPageWikiLink Q76560.
- Q6125539 wikiPageWikiLink Q8047.
- Q6125539 wikiPageWikiLink Q8386.
- Q6125539 wikiPageWikiLink Q8660039.
- Q6125539 comment "Reversible inhibitors of monoamine oxidase A (RIMAs) are a class of drugs which selectively and reversibly inhibit the enzyme monoamine oxidase A (MAO-A). They are used clinically in the treatment of depression and dysthymia, though they have not gained widespread market share in the United States.".
- Q6125539 label "Reversible inhibitor of monoamine oxidase A".
- Q6125539 depiction Moclobemide.svg.