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- Q5876149 subject Q7069096.
- Q5876149 abstract "In membrane biology, the Hodgkin cycle is a key component of membrane physiology, identified by British physiologist and biophysicist Sir Alan Lloyd Hodgkin, which describes bioelectrical impulses.The Hodgkin cycle represents a positive feedback loop in which an initial membrane depolarization leads to uncontrolled deflection of the membrane potential to near VNa. The initial depolarization must reach or surpass threshold in order to activate voltage-gated Na+ channels. Opening of Na+ channels allows Na+ inflow, which, in turn, further depolarizes the membrane. Additional depolarization activates additional Na+ channels. This cycle leads to a very rapid rise in Na+ conductance (gNa), which moves the membrane potential close to VNa. The cycle is broken when the membrane potential reaches to the sodium equilibrium potential and potassium channels open to re-polarize the membrane potential. This positive feedback loop means that the closer these voltage-gated Na+ channels are to each other, the lower the threshold of activation.It is important to understand membrane physiology in order to understand how cells communicate with one another. Signalling between cells, such as neurons for example, revolves around changes in the electrical potentials across their membranes. In a healthy cell at rest, the intracellular area is usually negatively charged relative to the extracellular region. Depolarization refers to when the intracellular region becomes less negatively charged relative to the extracellular region. The concentration of sodium ions is intimately related to the electrical potential across a membrane. Depolarization often occurs via the influx of sodium ions to the intracellular region. Given sodium ions have a positive charge, the intracellular region becomes less negatively charged relative to the extracellular region.".
- Q5876149 thumbnail Hodgkin-Cycle.jpg?width=300.
- Q5876149 wikiPageWikiLink Q1385443.
- Q5876149 wikiPageWikiLink Q16863771.
- Q5876149 wikiPageWikiLink Q1754002.
- Q5876149 wikiPageWikiLink Q193650.
- Q5876149 wikiPageWikiLink Q210973.
- Q5876149 wikiPageWikiLink Q3686031.
- Q5876149 wikiPageWikiLink Q3824358.
- Q5876149 wikiPageWikiLink Q389844.
- Q5876149 wikiPageWikiLink Q423778.
- Q5876149 wikiPageWikiLink Q424960.
- Q5876149 wikiPageWikiLink Q43054.
- Q5876149 wikiPageWikiLink Q4661718.
- Q5876149 wikiPageWikiLink Q521.
- Q5876149 wikiPageWikiLink Q5527425.
- Q5876149 wikiPageWikiLink Q7069096.
- Q5876149 wikiPageWikiLink Q7100.
- Q5876149 wikiPageWikiLink Q83183.
- Q5876149 wikiPageWikiLink Q918004.
- Q5876149 comment "In membrane biology, the Hodgkin cycle is a key component of membrane physiology, identified by British physiologist and biophysicist Sir Alan Lloyd Hodgkin, which describes bioelectrical impulses.The Hodgkin cycle represents a positive feedback loop in which an initial membrane depolarization leads to uncontrolled deflection of the membrane potential to near VNa. The initial depolarization must reach or surpass threshold in order to activate voltage-gated Na+ channels.".
- Q5876149 label "Hodgkin cycle".
- Q5876149 depiction Hodgkin-Cycle.jpg.