Matches in DBpedia 2016-04 for { <http://wikidata.dbpedia.org/resource/Q5874320> ?p ?o }
Showing triples 1 to 39 of
39
with 100 triples per page.
- Q5874320 subject Q8395796.
- Q5874320 abstract "Lysostaphin (EC 3.4.24.75, glycyl-glycine endopeptidase) is a Staphylococcus simulans metalloendopeptidase. It can function as an antimicrobial against Staphylococcus aureus.Lysostaphin is a 27 KDa glycylglycine endopeptidase, an antibacterial enzyme which is capable of cleaving the crosslinking pentaglycin bridges in the cell wall of Staphylococci. Lysostaphin was first isolated from a culture of Staphylococcus simulans by Schindler and Schuhardt in 1964. S. aureus cell walls contain high proportions of pentaglycin, making lysostaphin a highly effective agent against both actively growing and quiescent bacteria.Staphylococcal infections of both Staphylococcus aureus and Staphylococcus epidermidis continue to be a major issue in clinical settings, particularly those with implantable devices. Staphylococci cause a significant percentage of device infections, and like many other pathogens, rather than living as free planktonic cells within the host they have the ability to form a multilayered community of sessile bacteria cells known as a biofilm on implantable devices. Once a "Staphylococcal" biofilm has formed on an implanted medical device, it is difficult to disrupt due to its antibiotic resistance and protection against bacterial action.Many studies have been previously published on lysostaphin since its isolation, both in vitro and in vivo. Lysostaphin has been shown to eradicate susceptible S. aureus biofilms. It has also been reported to be effective in disrupting S. epidermidis biofilms in vitro, albeit at higher concentrations of the enzyme. Compared to commonly used antibiotics such as vancomycin, lysostaphin has been shown to demonstrate greater antibacterial activity in vitro. The enzyme has demonstrated effectiveness against methicillin susceptible S. aureus (MSSA) and methicillin resistant S. aureus (MRSA) mediated keratitis in vivo in a rabbit model. Additionally, it has been shown that lysostaphin combined with antimicrobials such as cefazolin, clarithromycin, doxycycline, levofloxacin, linezolid and quinuprisitin/dalfopristin has a synergistic effect for MSSA strains of the bacteria. A study published by Belyansky et al. illustrated that a lysostaphin bound mesh demonstrated dramatic preservation results in a rat model.Using lyosptaphin to treat "Staphylococcal" biofilm associated infections may prove to be preferable to using antibiotics as it may be possible to administer the enzyme at relatively low doses and disrupt a staphylococcal bioflim, therefore eliminating the need for surgical removal of the infected device.".
- Q5874320 ecNumber "3.4.24.75".
- Q5874320 thumbnail 1QWY.png?width=300.
- Q5874320 wikiPageExternalLink merops.cgi?id=M23.004.
- Q5874320 wikiPageExternalLink explore.do?structureId=1QWY.
- Q5874320 wikiPageWikiLink Q118551.
- Q5874320 wikiPageWikiLink Q12187.
- Q5874320 wikiPageWikiLink Q131915.
- Q5874320 wikiPageWikiLink Q16877548.
- Q5874320 wikiPageWikiLink Q188121.
- Q5874320 wikiPageWikiLink Q2268276.
- Q5874320 wikiPageWikiLink Q25712.
- Q5874320 wikiPageWikiLink Q380775.
- Q5874320 wikiPageWikiLink Q411377.
- Q5874320 wikiPageWikiLink Q415739.
- Q5874320 wikiPageWikiLink Q417262.
- Q5874320 wikiPageWikiLink Q422442.
- Q5874320 wikiPageWikiLink Q424027.
- Q5874320 wikiPageWikiLink Q424193.
- Q5874320 wikiPageWikiLink Q467410.
- Q5874320 wikiPageWikiLink Q5210829.
- Q5874320 wikiPageWikiLink Q595158.
- Q5874320 wikiPageWikiLink Q665455.
- Q5874320 wikiPageWikiLink Q6822865.
- Q5874320 wikiPageWikiLink Q757838.
- Q5874320 wikiPageWikiLink Q8047.
- Q5874320 wikiPageWikiLink Q8395796.
- Q5874320 ecNumber "3.4".
- Q5874320 name "Lysostaphin".
- Q5874320 type Biomolecule.
- Q5874320 type Enzyme.
- Q5874320 type Thing.
- Q5874320 type Q206229.
- Q5874320 type Q8047.
- Q5874320 comment "Lysostaphin (EC 3.4.24.75, glycyl-glycine endopeptidase) is a Staphylococcus simulans metalloendopeptidase. It can function as an antimicrobial against Staphylococcus aureus.Lysostaphin is a 27 KDa glycylglycine endopeptidase, an antibacterial enzyme which is capable of cleaving the crosslinking pentaglycin bridges in the cell wall of Staphylococci. Lysostaphin was first isolated from a culture of Staphylococcus simulans by Schindler and Schuhardt in 1964. S.".
- Q5874320 label "Lysostaphin".
- Q5874320 depiction 1QWY.png.
- Q5874320 name "Lysostaphin".