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- Q583864 subject Q8395845.
- Q583864 subject Q8802898.
- Q583864 abstract "FKBP, or FK506 binding protein, is a family of proteins that have prolyl isomerase activity and are related to the cyclophilins in function, though not in amino acid sequence. FKBPs have been identified in many eukaryotes from yeast to humans and function as protein folding chaperones for proteins containing proline residues. Along with cyclophilin, FKBPs belong to the immunophilin family.FKBP12 is notable in humans for binding the immunosuppressant molecule tacrolimus (originally designated FK506), which is used in treating patients after organ transplant and patients suffering from autoimmune disorders. Tacrolimus has been found to reduce episodes of organ rejection over a related treatment, the drug ciclosporin, which binds cyclophilin. Both the FKBP-tacrolimus complex and the ciclosporin-cyclophilin complex inhibit a phosphatase called calcineurin, thus blocking signal transduction in the T-lymphocyte transduction pathway. This therapeutic role is not related to prolyl isomerase activity.".
- Q583864 symbol "FKBP_C".
- Q583864 thumbnail Fkbp-surface-1fkj.png?width=300.
- Q583864 wikiPageExternalLink drugs.htm.
- Q583864 wikiPageWikiLink Q105196.
- Q583864 wikiPageWikiLink Q116672.
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- Q583864 wikiPageWikiLink Q192360.
- Q583864 wikiPageWikiLink Q367700.
- Q583864 wikiPageWikiLink Q3774751.
- Q583864 wikiPageWikiLink Q411648.
- Q583864 wikiPageWikiLink Q420566.
- Q583864 wikiPageWikiLink Q422476.
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- Q583864 wikiPageWikiLink Q5.
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- Q583864 wikiPageWikiLink Q5426016.
- Q583864 wikiPageWikiLink Q715347.
- Q583864 wikiPageWikiLink Q8054.
- Q583864 wikiPageWikiLink Q828130.
- Q583864 wikiPageWikiLink Q8395845.
- Q583864 wikiPageWikiLink Q847556.
- Q583864 wikiPageWikiLink Q8802898.
- Q583864 symbol "FKBP_C".
- Q583864 type Biomolecule.
- Q583864 type Protein.
- Q583864 type Thing.
- Q583864 type Q206229.
- Q583864 type Q8054.
- Q583864 comment "FKBP, or FK506 binding protein, is a family of proteins that have prolyl isomerase activity and are related to the cyclophilins in function, though not in amino acid sequence. FKBPs have been identified in many eukaryotes from yeast to humans and function as protein folding chaperones for proteins containing proline residues.".
- Q583864 label "FKBP".
- Q583864 depiction Fkbp-surface-1fkj.png.