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- Q583248 subject Q7335439.
- Q583248 subject Q7335467.
- Q583248 subject Q8754927.
- Q583248 abstract "U2 spliceosomal RNA is a small nuclear RNA (snRNA) component of the spliceosome (involved in pre-mRNA splicing). Complementary binding between U2 snRNA (in an area lying towards the 5' end but 3' to hairpin I) and the branchpoint sequence (BPS) of the intron results in the bulging out of an unpaired adenosine, on the BPS, which initiates a nucleophilic attack at the intronic 5' splice site, thus starting the first of two transesterification reactions that mediate splicing.After recognition of the pre-mRNA 5’ splice site by U1 snRNA, U1 snRNA binds to this point. As soon as this bond forms, U2 snRNA binds to the branch point site, which forms a bulge at the branch point binding sequence. In addition, U6 snRNA associates with U2 snRNA and the 5’ splice site through base pairing interaction. The association of U2 snRNP with the pre-mRNA branch site plays a fundamental role during splicing assembly since it directly participates in chemical catalysis. Moreover, U2 snRNP undergoes several rearrangements along with the recognition of the branch point adenosine and formation of the base pair interaction between U2 snRNA and consensus sequence within the intron.".
- Q583248 thumbnail RF00004.jpg?width=300.
- Q583248 wikiPageExternalLink u2.html.
- Q583248 wikiPageWikiLink Q15712714.
- Q583248 wikiPageWikiLink Q188928.
- Q583248 wikiPageWikiLink Q190012.
- Q583248 wikiPageWikiLink Q19088.
- Q583248 wikiPageWikiLink Q207551.
- Q583248 wikiPageWikiLink Q237218.
- Q583248 wikiPageWikiLink Q238406.
- Q583248 wikiPageWikiLink Q2644277.
- Q583248 wikiPageWikiLink Q2819374.
- Q583248 wikiPageWikiLink Q2819378.
- Q583248 wikiPageWikiLink Q284578.
- Q583248 wikiPageWikiLink Q4995178.
- Q583248 wikiPageWikiLink Q591576.
- Q583248 wikiPageWikiLink Q7187.
- Q583248 wikiPageWikiLink Q7335439.
- Q583248 wikiPageWikiLink Q7335467.
- Q583248 wikiPageWikiLink Q745930.
- Q583248 wikiPageWikiLink Q8754927.
- Q583248 wikiPageWikiLink Q915868.
- Q583248 comment "U2 spliceosomal RNA is a small nuclear RNA (snRNA) component of the spliceosome (involved in pre-mRNA splicing).".
- Q583248 label "U2 spliceosomal RNA".
- Q583248 depiction RF00004.jpg.