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- Q5774806 subject Q6431034.
- Q5774806 abstract "Human leukocyte antigens (HLA) began as a list of antigens identified as a result of transplant rejection. The antigens were initially identified by categorizing and performing massive statistical analyses on interactions between blood types. This process is based upon the principle of serotypes. HLA are not typical antigens, like those found on surface of infectious agents. HLAs are alloantigens, they vary from individual to individual as a result of genetic differences.An organ called the thymus is responsible for ensuring that any t-cells that attack self proteins are not allowed to live. In essence, every individual's immune system is tuned to the specific set of HLA and self proteins produced by that individual. (For more information please see immune tolerance). Where this goes wrong is when tissues are transferred to another person. Since individuals almost always have different "banks" of HLAs, the immune system of the recipient recognizes the transplanted tissue as non-self and destroys the offending tissue. It was through the realization of this that HLAs were discovered.".
- Q5774806 thumbnail Peter_Brian_Medawar.jpg?width=300.
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- Q5774806 comment "Human leukocyte antigens (HLA) began as a list of antigens identified as a result of transplant rejection. The antigens were initially identified by categorizing and performing massive statistical analyses on interactions between blood types. This process is based upon the principle of serotypes. HLA are not typical antigens, like those found on surface of infectious agents.".
- Q5774806 label "History and naming of human leukocyte antigens".
- Q5774806 depiction Peter_Brian_Medawar.jpg.