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- Q5710202 subject Q7216147.
- Q5710202 abstract "The T-Lymphocyte Helper/Suppressor Profile (Helper/Suppressor ratio, T4:T8 ratio, CD4:CD8 ratio) is a basic laboratory test in which the percentage of CD3-positive lymphocytes in the blood positive for CD4 (T helper cells) and CD8 (a class of regulatory T cells) are counted and compared. Normal values (95% confidence intervals) are approximately 30-60% CD4 and 10-30% CD8 depending on age (ratio 0.9 to 3.7 in adults). One reason for abnormal results is the loss of CD4-positive cells to the Human Immunodeficiency Virus [HIV] infection.The loss of CD4-positive cells to HIV infection can result in various distortions in the ratio, as in the initial period, production of HIV specific CD8 positive cells will cause a large fall in the ratio, but subsequent immunosuppression over time may lead to overall non production of immune cells and inversion of the ratio. It has been shown that the degree of inversion of this ratio in individuals on antiretroviral therapy is indicative of the age of the infection and independently predictive of mortality associated with non HIV events.".
- Q5710202 wikiPageWikiLink Q1550619.
- Q5710202 wikiPageWikiLink Q21788706.
- Q5710202 wikiPageWikiLink Q417800.
- Q5710202 wikiPageWikiLink Q419458.
- Q5710202 wikiPageWikiLink Q632518.
- Q5710202 wikiPageWikiLink Q715347.
- Q5710202 wikiPageWikiLink Q7216147.
- Q5710202 comment "The T-Lymphocyte Helper/Suppressor Profile (Helper/Suppressor ratio, T4:T8 ratio, CD4:CD8 ratio) is a basic laboratory test in which the percentage of CD3-positive lymphocytes in the blood positive for CD4 (T helper cells) and CD8 (a class of regulatory T cells) are counted and compared. Normal values (95% confidence intervals) are approximately 30-60% CD4 and 10-30% CD8 depending on age (ratio 0.9 to 3.7 in adults).".
- Q5710202 label "Helper/suppressor ratio".