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- Q5628930 subject Q8431759.
- Q5628930 subject Q9089720.
- Q5628930 abstract "HAMLET (Human Alpha-lactalbumin Made LEthal to Tumor cells) is a complex between alpha-lactalbumin and oleic acid that induces cell death in tumor cells, but not in healthy cells.HAMLET is a possible chemotherapeutic agent with the ability to kill cancer cells. Alpha-lactalbumin is the primary protein component of human milk. In a 1995 study, it was noted that multimeric alpha-lactalbumin (MAL), a compound isolated from a fraction of human milk called casein, induced what appeared to be apoptosis in human lung carcinoma cells, pneumococcus bacteria, and other pathogens, while leaving healthy, differentiated cells unaffected. It has been the perfect cure in this case. The active component responsible for the tumoricidal activity was found in 2000 and found to be a complex of alpha-lactalbumin and oleic acid.Endogenous human alpha-lactalbumin is complexed with a calcium ion and serves as a cofactor in lactose synthesis, but has no tumoricidal properties. The alpha-lactalbumin must be partially unfolded to allow for release of the calcium ion and replacement with an oleic acid molecule. The partially folded conformation is essential to the cytotoxicity of HAMLET, as mutagenesis studies have shown that completely unfolded alpha-lacalbumin does not retain the functional properties of HAMLET. The oleic acid is necessary for stabilizing this molecule in this partially unfolded state. Over the past several years, additional work has further characterized the structure and function of HAMLET and its clinical applications are currently under investigation. However, in order to develop effective therapies, more must be known about the mechanism of action of HAMLET.".
- Q5628930 wikiPageWikiLink Q14599311.
- Q5628930 wikiPageWikiLink Q14818098.
- Q5628930 wikiPageWikiLink Q14819361.
- Q5628930 wikiPageWikiLink Q14863436.
- Q5628930 wikiPageWikiLink Q14876086.
- Q5628930 wikiPageWikiLink Q14897677.
- Q5628930 wikiPageWikiLink Q177900.
- Q5628930 wikiPageWikiLink Q193970.
- Q5628930 wikiPageWikiLink Q207688.
- Q5628930 wikiPageWikiLink Q2354337.
- Q5628930 wikiPageWikiLink Q246181.
- Q5628930 wikiPageWikiLink Q25805.
- Q5628930 wikiPageWikiLink Q271794.
- Q5628930 wikiPageWikiLink Q282142.
- Q5628930 wikiPageWikiLink Q288322.
- Q5628930 wikiPageWikiLink Q309110.
- Q5628930 wikiPageWikiLink Q3569101.
- Q5628930 wikiPageWikiLink Q36293.
- Q5628930 wikiPageWikiLink Q39572.
- Q5628930 wikiPageWikiLink Q407280.
- Q5628930 wikiPageWikiLink Q410862.
- Q5628930 wikiPageWikiLink Q5421150.
- Q5628930 wikiPageWikiLink Q5867482.
- Q5628930 wikiPageWikiLink Q595158.
- Q5628930 wikiPageWikiLink Q8431759.
- Q5628930 wikiPageWikiLink Q9089720.
- Q5628930 wikiPageWikiLink Q912796.
- Q5628930 wikiPageWikiLink Q974135.
- Q5628930 comment "HAMLET (Human Alpha-lactalbumin Made LEthal to Tumor cells) is a complex between alpha-lactalbumin and oleic acid that induces cell death in tumor cells, but not in healthy cells.HAMLET is a possible chemotherapeutic agent with the ability to kill cancer cells. Alpha-lactalbumin is the primary protein component of human milk.".
- Q5628930 label "HAMLET (protein complex)".