Matches in DBpedia 2016-04 for { <http://wikidata.dbpedia.org/resource/Q5515257> ?p ?o }
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- Q5515257 subject Q7145142.
- Q5515257 subject Q7215860.
- Q5515257 subject Q8479056.
- Q5515257 subject Q8788974.
- Q5515257 subject Q8918235.
- Q5515257 subject Q9546190.
- Q5515257 abstract "Gabapentin enacarbil (Horizant (in USA), Regnite (in Japan), formerly known as XP-13512) is a prodrug for the anticonvulsant and analgesic drug gabapentin. It was designed for increased oral bioavailability over gabapentin, and human trials showed it to produce extended release of gabapentin with almost twice the overall bioavailability, especially when taken with a fatty meal. Gabapentin enacarbil has passed human clinical trials for the treatment of restless legs syndrome, and initial results have shown it to be well tolerated and reasonably effective.Gabapentin enacarbil was denied approval by the U.S. Food and Drug Administration (FDA) in February 2010, citing concerns about possible increased cancer risk shown by some animal studies. Similar concerns had been raised about gabapentin itself in the past, but were felt to be outweighed by its clinical utility as an anticonvulsant, whereas the treatment of restless legs syndrome was not seen to justify the same kind of risk.On April 6, 2011, Xenoport received FDA approval for Horizant (gabapentin enacarbil) for the treatment of moderate-to-severe restless legs syndrome.On June 7, 2012, FDA approved Horizant for the treatment of postherpetic neuralgia in adults.".
- Q5515257 casNumber "478296-72-9".
- Q5515257 chEBI "68840".
- Q5515257 fdaUniiCode "75OCL1SPBQ".
- Q5515257 iupacName "(1-{[({(1RS)-1-[isobutyryloxy]ethoxy}carbonyl)".
- Q5515257 iupacName "amino]methyl}cyclohexyl)acetic acid".
- Q5515257 pubchem "9883933".
- Q5515257 thumbnail Gabapentin_enacarbil.svg?width=300.
- Q5515257 wikiPageWikiLink Q1714245.
- Q5515257 wikiPageWikiLink Q173235.
- Q5515257 wikiPageWikiLink Q204711.
- Q5515257 wikiPageWikiLink Q30612.
- Q5515257 wikiPageWikiLink Q410352.
- Q5515257 wikiPageWikiLink Q461809.
- Q5515257 wikiPageWikiLink Q4637181.
- Q5515257 wikiPageWikiLink Q4812635.
- Q5515257 wikiPageWikiLink Q576618.
- Q5515257 wikiPageWikiLink Q603741.
- Q5515257 wikiPageWikiLink Q7145142.
- Q5515257 wikiPageWikiLink Q7215860.
- Q5515257 wikiPageWikiLink Q8479056.
- Q5515257 wikiPageWikiLink Q8788974.
- Q5515257 wikiPageWikiLink Q8918235.
- Q5515257 wikiPageWikiLink Q916280.
- Q5515257 wikiPageWikiLink Q9377.
- Q5515257 wikiPageWikiLink Q9546190.
- Q5515257 casNumber "478296".
- Q5515257 chebi "68840".
- Q5515257 iupacName "acetic acid".
- Q5515257 pubchem "9883933".
- Q5515257 unii "75".
- Q5515257 type ChemicalSubstance.
- Q5515257 type Drug.
- Q5515257 type ChemicalObject.
- Q5515257 type Thing.
- Q5515257 type Q8386.
- Q5515257 comment "Gabapentin enacarbil (Horizant (in USA), Regnite (in Japan), formerly known as XP-13512) is a prodrug for the anticonvulsant and analgesic drug gabapentin. It was designed for increased oral bioavailability over gabapentin, and human trials showed it to produce extended release of gabapentin with almost twice the overall bioavailability, especially when taken with a fatty meal.".
- Q5515257 label "Gabapentin enacarbil".
- Q5515257 depiction Gabapentin_enacarbil.svg.