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- Q5443558 subject Q5856563.
- Q5443558 subject Q6897536.
- Q5443558 subject Q7486806.
- Q5443558 subject Q8919936.
- Q5443558 subject Q8971959.
- Q5443558 subject Q9052781.
- Q5443558 abstract "Fenobam is an imidazole derivative developed by McNeil Laboratories in the late 1970s as a novel anxiolytic drug with an at-the-time-unidentified molecular target in the brain. Subsequently, it was determined that fenobam acts as a potent and selective negative allosteric modulator of the metabotropic glutamate receptor subtype mGluR5, and it has been used as a lead compound for the development of a range of newer mGluR5 antagonists.Fenobam has anxiolytic effects comparable to those of benzodiazepine drugs, but was never commercially marketed for the treatment of anxiety due to dose-limiting side effects such as amnesia and psychotomimetic symptoms. Following the discovery of its activity as a potent negative allosteric modulator of mGluR5, fenobam has been re-investigated for many applications, with its profile of combined antidepressant, anxiolytic, analgesic and anti-addictive effects potentially useful given the common co-morbidity of these symptoms. It has also shown promising initial results in the treatment of fragile X syndrome. It was developed by a team at McNeil Laboratories in the 1970s.".
- Q5443558 iupacName "1-(3-chlorophenyl)-3-(3-methyl-5-oxo-4H-imidazol-2-yl)urea".
- Q5443558 thumbnail Fenobam.svg?width=300.
- Q5443558 wikiPageWikiLink Q1258877.
- Q5443558 wikiPageWikiLink Q18026547.
- Q5443558 wikiPageWikiLink Q2033959.
- Q5443558 wikiPageWikiLink Q2066956.
- Q5443558 wikiPageWikiLink Q221472.
- Q5443558 wikiPageWikiLink Q2649417.
- Q5443558 wikiPageWikiLink Q328692.
- Q5443558 wikiPageWikiLink Q5856563.
- Q5443558 wikiPageWikiLink Q62903.
- Q5443558 wikiPageWikiLink Q6802523.
- Q5443558 wikiPageWikiLink Q6897536.
- Q5443558 wikiPageWikiLink Q7486806.
- Q5443558 wikiPageWikiLink Q83871.
- Q5443558 wikiPageWikiLink Q8919936.
- Q5443558 wikiPageWikiLink Q8971959.
- Q5443558 wikiPageWikiLink Q903238.
- Q5443558 wikiPageWikiLink Q9052781.
- Q5443558 iupacname "1".
- Q5443558 type ChemicalCompound.
- Q5443558 type ChemicalSubstance.
- Q5443558 type ChemicalObject.
- Q5443558 type Thing.
- Q5443558 type Q11173.
- Q5443558 comment "Fenobam is an imidazole derivative developed by McNeil Laboratories in the late 1970s as a novel anxiolytic drug with an at-the-time-unidentified molecular target in the brain.".
- Q5443558 label "Fenobam".
- Q5443558 depiction Fenobam.svg.