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- Q5426661 subject Q8420217.
- Q5426661 abstract "FMS-like tyrosine kinase 3 ligand (Flt3l) is a small molecule that acts as a growth factor that increases the number of immune cells (lymphocytes (B cells and T cells)) by activating the hematopoietic progenitors.It acts by binding to FLT3 aka CD135 which is found on what (in mice) are called multipotent progenitor (MPP) and common lymphoid progenitor (CLP) cells.It also induces the mobilization of the hematopoietic progenitors and stem cells in vivo which may help the system to kill cancer cells.FLT3L is crucial for steady-state plasmacytoid dendritic cell (pDC) and classical dendritic cell (cDC) development. A lack of FLT3L results in low levels of dendritic cells.Flt3l in parasite clearanceFlt3l and its receptor are involved in the mammalian immune response to malaria. In strains of plasmodium, Flt3l was shown to be released from mast cells and cause the expansion of dendritic cells, leading to the activation of CD8+ T cells. The same paper suggested that Flt3L release was caused by stimulation of mast cells with uric acid, produced from a precursor secreted by the plasmodium parasite. .".
- Q5426661 wikiPageExternalLink pathway.php?sn=FLT3_Signaling.
- Q5426661 wikiPageWikiLink Q12045567.
- Q5426661 wikiPageWikiLink Q12156.
- Q5426661 wikiPageWikiLink Q14912399.
- Q5426661 wikiPageWikiLink Q188930.
- Q5426661 wikiPageWikiLink Q191989.
- Q5426661 wikiPageWikiLink Q193529.
- Q5426661 wikiPageWikiLink Q408378.
- Q5426661 wikiPageWikiLink Q410305.
- Q5426661 wikiPageWikiLink Q48196.
- Q5426661 wikiPageWikiLink Q506253.
- Q5426661 wikiPageWikiLink Q5976738.
- Q5426661 wikiPageWikiLink Q715347.
- Q5426661 wikiPageWikiLink Q8420217.
- Q5426661 comment "FMS-like tyrosine kinase 3 ligand (Flt3l) is a small molecule that acts as a growth factor that increases the number of immune cells (lymphocytes (B cells and T cells)) by activating the hematopoietic progenitors.It acts by binding to FLT3 aka CD135 which is found on what (in mice) are called multipotent progenitor (MPP) and common lymphoid progenitor (CLP) cells.It also induces the mobilization of the hematopoietic progenitors and stem cells in vivo which may help the system to kill cancer cells.FLT3L is crucial for steady-state plasmacytoid dendritic cell (pDC) and classical dendritic cell (cDC) development. ".
- Q5426661 label "FMS-like tyrosine kinase 3 ligand".