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- Q54063 subject Q14946667.
- Q54063 subject Q9142579.
- Q54063 abstract "DLX is a family of homeodomain transcription factors which are related to the Drosophila distal-less (Dll) gene.Distal-less itself, and its homologues, is involved in limb development in most of the major phyla, including vertebrates — suggesting that it was involved in appendage growth in an early bilaterial ancestor.The family has been related to a number of developmental features.The family seems to be well preserved across species.Known members of the family include DLX1 to DLX6. They form two-gene clusters (bigene clusters) with each other. There are DLX1-DLX2, DLX3-DLX4, DLX5-DLX6 clusters in vertebrates. Each of those are linked to a specific Hox gene cluster. In higher fishes, like Zebrafish, there are a couple of additional DLX genes, DLX5 and DLX8. In zebrafish the orthologous genes to vertebrate DLX5-DLX6 are DLX4 and DLX6, which form a bigene cluster in zebrafish. These additional genes are not linked with each other, or any other DLX gene.DLX4, DLX7, DLX8 and DLX9 are the same gene in vertebrates. They're named differently, because every time the same gene was found, the researchers thought they had found a new gene.DLX genes are involved in craniofacial morphogenesis and the tangential migration of interneurons from the subpallium to the pallium during vertebrate brain development. It has been suggested that DLX promotes the migration of interneurons by repressing a set of proteins that are normally expressed in terminally differentiated neurons and act to promote the outgrowth of dendrites and axons. Mice lacking DLX1 exhibit electrophysiological and histological evidence consistent with delayed-onset epilepsy.DLX2 has been associated with a number of areas including development of the zona limitans intrathalamica and the prethalamus.DLX5 and DLX6 genes are necessary for normal formation of the mandible in vertebrates.DLX7 is expressed in bone marrow.".
- Q54063 wikiPageWikiLink Q1066549.
- Q54063 wikiPageWikiLink Q12821248.
- Q54063 wikiPageWikiLink Q1345738.
- Q54063 wikiPageWikiLink Q14946667.
- Q54063 wikiPageWikiLink Q1500732.
- Q54063 wikiPageWikiLink Q1501261.
- Q54063 wikiPageWikiLink Q169444.
- Q54063 wikiPageWikiLink Q178999.
- Q54063 wikiPageWikiLink Q17914015.
- Q54063 wikiPageWikiLink Q17914016.
- Q54063 wikiPageWikiLink Q17914017.
- Q54063 wikiPageWikiLink Q17914018.
- Q54063 wikiPageWikiLink Q17914019.
- Q54063 wikiPageWikiLink Q17914020.
- Q54063 wikiPageWikiLink Q253149.
- Q54063 wikiPageWikiLink Q2602063.
- Q54063 wikiPageWikiLink Q312154.
- Q54063 wikiPageWikiLink Q407384.
- Q54063 wikiPageWikiLink Q41571.
- Q54063 wikiPageWikiLink Q546523.
- Q54063 wikiPageWikiLink Q8073847.
- Q54063 wikiPageWikiLink Q898769.
- Q54063 wikiPageWikiLink Q9142579.
- Q54063 comment "DLX is a family of homeodomain transcription factors which are related to the Drosophila distal-less (Dll) gene.Distal-less itself, and its homologues, is involved in limb development in most of the major phyla, including vertebrates — suggesting that it was involved in appendage growth in an early bilaterial ancestor.The family has been related to a number of developmental features.The family seems to be well preserved across species.Known members of the family include DLX1 to DLX6.".
- Q54063 label "DLX gene family".