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- Q5401760 subject Q6938881.
- Q5401760 subject Q7162167.
- Q5401760 subject Q8343807.
- Q5401760 subject Q8424896.
- Q5401760 abstract "Estradiol cypionate (INN, USAN) (brand names Depo-Estradiol, Depofemin, Estradep, and many others), or estradiol cipionate, is a synthetic ester, specifically the 3-cyclopentylpropanoyl ester, of the natural estrogen, estradiol. It was first introduced in 1952 by Upjohn in the United States, and has been in widespread use since. Estradiol cypionate behaves as a sustained-release prodrug to estradiol, and therefore is considered to be natural estrogen.Estradiol cypionate is absorbed more slowly than estradiol itself, and for that reason, can be administered less often. Compared to other commonly used estradiol esters, via the intramuscular route, estradiol cypionate was found to have the longest duration of action with a duration of ~11 days, while estradiol benzoate and estradiol valerate were found to last for 4–5 days and 7–8 days, respectively. Estradiol cypionate, as a depot injection, has been found to have equivalent effectiveness and pharmacokinetics (e.g., duration) via subcutaneous and intramuscular routes. However, subcutaneous injection is generally regarded as easier and less painful relative to intramuscular injection, and for these reasons, may result in comparatively greater patient compliance.Lunelle and Cyclofem are combination formulations of 4 mg estradiol cypionate and 25 mg medroxyprogesterone acetate for intramuscular use as long-lasting (once-monthly) contraceptives. With these formulations, estradiol levels peak 2 days post-administration at mean serum levels of 247 pg/mL. The terminal half-life of estradiol with these formulations is approximately 8 days, and plasma estradiol levels return to baseline (typically about 100 pg/mL) by 14 days post-administration. At 28 days post-administration, estradiol levels reach a low of 40 to 55 pg/mL.".
- Q5401760 atcPrefix "None".
- Q5401760 casNumber "313-06-4".
- Q5401760 iupacName "(17β)-3-hydroxyestra-1,3,5(10)-trien-17-yl 3-cyclopentylpropanoate".
- Q5401760 pubchem "9403".
- Q5401760 thumbnail Estradiol_17_beta-cypionate.svg?width=300.
- Q5401760 wikiPageWikiLink Q101487.
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- Q5401760 wikiPageWikiLink Q16266700.
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- Q5401760 wikiPageWikiLink Q30.
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- Q5401760 wikiPageWikiLink Q5200280.
- Q5401760 wikiPageWikiLink Q5401768.
- Q5401760 wikiPageWikiLink Q5401844.
- Q5401760 wikiPageWikiLink Q603741.
- Q5401760 wikiPageWikiLink Q621636.
- Q5401760 wikiPageWikiLink Q6938881.
- Q5401760 wikiPageWikiLink Q7162167.
- Q5401760 wikiPageWikiLink Q7292449.
- Q5401760 wikiPageWikiLink Q824258.
- Q5401760 wikiPageWikiLink Q8343807.
- Q5401760 wikiPageWikiLink Q8424896.
- Q5401760 wikiPageWikiLink Q901227.
- Q5401760 wikiPageWikiLink Q9635.
- Q5401760 atcPrefix "None".
- Q5401760 casNumber "0313-06-04".
- Q5401760 iupacName "-3".
- Q5401760 pubchem "9403".
- Q5401760 type ChemicalSubstance.
- Q5401760 type Drug.
- Q5401760 type ChemicalObject.
- Q5401760 type Thing.
- Q5401760 type Q8386.
- Q5401760 comment "Estradiol cypionate (INN, USAN) (brand names Depo-Estradiol, Depofemin, Estradep, and many others), or estradiol cipionate, is a synthetic ester, specifically the 3-cyclopentylpropanoyl ester, of the natural estrogen, estradiol. It was first introduced in 1952 by Upjohn in the United States, and has been in widespread use since.".
- Q5401760 label "Estradiol cypionate".
- Q5401760 depiction Estradiol_17_beta-cypionate.svg.