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- Q5383698 subject Q7217012.
- Q5383698 abstract "Cell polarity is a fundamental feature of many types of cells. Epithelial cells are one example of a polarized cell type, featuring distinct 'apical', 'lateral' and 'basal' plasma membrane domains. Epithelial cells connect to one another via their lateral membranes to form epithelial sheets that line cavities and surfaces throughout the animal body. Each plasma membrane domain has a distinct protein composition, giving them distinct properties and allowing directional transport of molecules across the epithelial sheet. How epithelial cells generate and maintain polarity remains unclear, but certain molecules have been found to play a key role.A variety of molecules are located at the apical membrane, but only a few key molecules act as determinants that are required to maintain the identity of the apical membrane and, thus, epithelial polarity. These molecules are the proteins Cdc42, atypical protein kinase C (aPKC), Par6, Par3/Bazooka/ASIP. Crumbs, "Stardust" and protein at tight junctions (PATJ). These molecules appear to form two distinct complexes: an aPKC-Par3-Par6 "aPKC" (or "Par") complex that also interacts with Cdc42; and a Crumbs-Stardust-PATJ "Crumbs" complex. Of these two complexes, the aPKC complex is the most important for epithelial polarity, being required even when the Crumbs complex is not. Crumbs is the only transmembrane protein in this list and the Crumbs complex serves as an apical cue to keep the aPKC complex apical during complex cellular shape changes.".
- Q5383698 wikiPageExternalLink NBK21054.
- Q5383698 wikiPageWikiLink Q1057.
- Q5383698 wikiPageWikiLink Q1141325.
- Q5383698 wikiPageWikiLink Q130888.
- Q5383698 wikiPageWikiLink Q14902794.
- Q5383698 wikiPageWikiLink Q15311701.
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- Q5383698 wikiPageWikiLink Q18039875.
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- Q5383698 wikiPageWikiLink Q369541.
- Q5383698 wikiPageWikiLink Q37525.
- Q5383698 wikiPageWikiLink Q40924.
- Q5383698 wikiPageWikiLink Q409715.
- Q5383698 wikiPageWikiLink Q41301.
- Q5383698 wikiPageWikiLink Q420877.
- Q5383698 wikiPageWikiLink Q45173.
- Q5383698 wikiPageWikiLink Q4735159.
- Q5383698 wikiPageWikiLink Q477946.
- Q5383698 wikiPageWikiLink Q58184.
- Q5383698 wikiPageWikiLink Q719725.
- Q5383698 wikiPageWikiLink Q7217012.
- Q5383698 wikiPageWikiLink Q7868.
- Q5383698 wikiPageWikiLink Q918004.
- Q5383698 comment "Cell polarity is a fundamental feature of many types of cells. Epithelial cells are one example of a polarized cell type, featuring distinct 'apical', 'lateral' and 'basal' plasma membrane domains. Epithelial cells connect to one another via their lateral membranes to form epithelial sheets that line cavities and surfaces throughout the animal body.".
- Q5383698 label "Epithelial polarity".