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- Q5308937 subject Q7300121.
- Q5308937 abstract "Druggability is a term used in drug discovery to describe a biological target (such as a protein) that is known to or is predicted to bind with high affinity to a drug. Furthermore by definition, the binding of the drug to a druggable target must alter the function of the target with a therapeutic benefit to the patient. The concept of druggability is most often restricted to small molecules (low molecular weight organic substances) but also has been extended to include biologic medical products such as therapeutic monoclonal antibodies.Drug discovery comprises a number of stages that lead from a biological hypothesis to an approved drug. Target identification is typically the starting point of the modern drug discovery process. Candidate targets may be selected based on a variety of experimental criteria. These criteria may include disease linkage (mutations in the protein are known to cause a disease), mechanistic rationale (for example, the protein is part of a regulatory pathway that is involved in the disease process), or genetic screens in model organisms. Disease relevance alone however is insufficient for a protein to become a drug target. In addition, the target must be druggable.".
- Q5308937 wikiPageExternalLink dgidb.org.
- Q5308937 wikiPageExternalLink tdrtargets.org.
- Q5308937 wikiPageExternalLink structure.
- Q5308937 wikiPageWikiLink Q1418791.
- Q5308937 wikiPageWikiLink Q1988322.
- Q5308937 wikiPageWikiLink Q213907.
- Q5308937 wikiPageWikiLink Q278487.
- Q5308937 wikiPageWikiLink Q3985153.
- Q5308937 wikiPageWikiLink Q417841.
- Q5308937 wikiPageWikiLink Q422248.
- Q5308937 wikiPageWikiLink Q4914007.
- Q5308937 wikiPageWikiLink Q5050812.
- Q5308937 wikiPageWikiLink Q5282122.
- Q5308937 wikiPageWikiLink Q6120337.
- Q5308937 wikiPageWikiLink Q679692.
- Q5308937 wikiPageWikiLink Q7300121.
- Q5308937 wikiPageWikiLink Q766195.
- Q5308937 wikiPageWikiLink Q7669877.
- Q5308937 wikiPageWikiLink Q8054.
- Q5308937 wikiPageWikiLink Q8386.
- Q5308937 wikiPageWikiLink Q896177.
- Q5308937 wikiPageWikiLink Q904407.
- Q5308937 comment "Druggability is a term used in drug discovery to describe a biological target (such as a protein) that is known to or is predicted to bind with high affinity to a drug. Furthermore by definition, the binding of the drug to a druggable target must alter the function of the target with a therapeutic benefit to the patient.".
- Q5308937 label "Druggability".