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- Q5281624 subject Q8747094.
- Q5281624 subject Q9089708.
- Q5281624 abstract "Discoidin domain (also known as F5/8 type C domain, or C2-like domain) is major domain of many blood coagulation factors.Blood coagulation factors V and VIII contain a C-terminal, twice repeated, domain of about 150 amino acids, which is often called "C2-like domain" (that is unrelated to C2 domain). In the Dictyostelium discoideum (Slime mold) cell adhesion protein discoidin, a related domain, named discoidin I-like domain, DLD, or DS, has been found which shares a common C-terminal region of about 110 amino acids with the FA58C domain, but whose N-terminal 40 amino acids are much less conserved. Similar domains have been detected in other extracellular and membrane proteins. In coagulation factors V and VIII the repeated domains compose part of a larger functional domain which promotes binding to anionic phospholipids on the surface of platelets and endothelial cells. The C-terminal domain of the second FA58C repeat (C2) of coagulation factor VIII has been shown to be responsible for phosphatidylserine-binding and essential for activity. FA58C contains two conserved cysteines in most proteins, which link the extremities of the domain by a disulfide bond. A further disulfide bond is located near the C-terminal of the second FA58C domain in MFGM Q08431.".
- Q5281624 symbol "F5_F8_type_C".
- Q5281624 thumbnail PDB_1fac_EBI.jpg?width=300.
- Q5281624 wikiPageWikiLink Q134351.
- Q5281624 wikiPageWikiLink Q14863039.
- Q5281624 wikiPageWikiLink Q14865116.
- Q5281624 wikiPageWikiLink Q17854856.
- Q5281624 wikiPageWikiLink Q179217.
- Q5281624 wikiPageWikiLink Q18030231.
- Q5281624 wikiPageWikiLink Q18031331.
- Q5281624 wikiPageWikiLink Q18032993.
- Q5281624 wikiPageWikiLink Q18033461.
- Q5281624 wikiPageWikiLink Q18033463.
- Q5281624 wikiPageWikiLink Q18036916.
- Q5281624 wikiPageWikiLink Q18037897.
- Q5281624 wikiPageWikiLink Q18042352.
- Q5281624 wikiPageWikiLink Q18048041.
- Q5281624 wikiPageWikiLink Q18050153.
- Q5281624 wikiPageWikiLink Q3307805.
- Q5281624 wikiPageWikiLink Q4836674.
- Q5281624 wikiPageWikiLink Q5008102.
- Q5281624 wikiPageWikiLink Q573409.
- Q5281624 wikiPageWikiLink Q8747094.
- Q5281624 wikiPageWikiLink Q9089708.
- Q5281624 symbol "F5_F8_type_C".
- Q5281624 type Biomolecule.
- Q5281624 type Protein.
- Q5281624 type Thing.
- Q5281624 type Q206229.
- Q5281624 type Q8054.
- Q5281624 comment "Discoidin domain (also known as F5/8 type C domain, or C2-like domain) is major domain of many blood coagulation factors.Blood coagulation factors V and VIII contain a C-terminal, twice repeated, domain of about 150 amino acids, which is often called "C2-like domain" (that is unrelated to C2 domain).".
- Q5281624 label "Discoidin domain".
- Q5281624 depiction PDB_1fac_EBI.jpg.