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- Q5269984 subject Q15211845.
- Q5269984 subject Q52363.
- Q5269984 subject Q8375173.
- Q5269984 abstract "Difluoromethylenedioxyamphetamine (DiFMDA) is a substituted derivative of methylenedioxyamphetamine (MDA), which was developed by Daniel Trachsel and coworkers, along with the corresponding fluorinated derivatives of MDMA, MDEA, BDB and MBDB, with the aim of finding a non-neurotoxic drug able to be used as a less harmful substitute for entactogenic drugs such as MDMA. Since a major route of the normal metabolism of these compounds is scission of the methylenedioxy ring, producing neurotoxic metabolites such as alpha-methyldopamine, it was hoped that the difluoromethylenedioxy bioisostere would show increased metabolic stability and less toxicity.These compounds have not yet been tested in animals to verify whether they show similar pharmacological activity to the non-fluorinated parent compounds, although in vitro binding studies show DFMDA to have a SERT affinity in between that of MDA and MDMA. However there is known to be a lack of bulk tolerance at this position of the molecule, shown by the generally reduced activity of the ethylidenedioxy and isopropylidenedioxy analogues. It is also now generally accepted that MDMA neurotoxicity results from a variety of different causes and is not solely due to accumulation of alpha-methyldopamine, making it unclear how much less neurotoxic DFMDA and related drugs would be in practice.".
- Q5269984 atcPrefix "none".
- Q5269984 casNumber "910393-51-0".
- Q5269984 iupacName "1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)propan-2-amine".
- Q5269984 thumbnail DFMDA.svg?width=300.
- Q5269984 wikiPageWikiLink Q14860818.
- Q5269984 wikiPageWikiLink Q15211845.
- Q5269984 wikiPageWikiLink Q223020.
- Q5269984 wikiPageWikiLink Q2664395.
- Q5269984 wikiPageWikiLink Q4353440.
- Q5269984 wikiPageWikiLink Q4634072.
- Q5269984 wikiPageWikiLink Q4639572.
- Q5269984 wikiPageWikiLink Q52363.
- Q5269984 wikiPageWikiLink Q6715120.
- Q5269984 wikiPageWikiLink Q6823980.
- Q5269984 wikiPageWikiLink Q69488.
- Q5269984 wikiPageWikiLink Q8375173.
- Q5269984 wikiPageWikiLink Q864401.
- Q5269984 wikiPageWikiLink Q903338.
- Q5269984 atcPrefix "none".
- Q5269984 casNumber "910393".
- Q5269984 iupacName "1".
- Q5269984 type ChemicalSubstance.
- Q5269984 type Drug.
- Q5269984 type ChemicalObject.
- Q5269984 type Thing.
- Q5269984 type Q8386.
- Q5269984 comment "Difluoromethylenedioxyamphetamine (DiFMDA) is a substituted derivative of methylenedioxyamphetamine (MDA), which was developed by Daniel Trachsel and coworkers, along with the corresponding fluorinated derivatives of MDMA, MDEA, BDB and MBDB, with the aim of finding a non-neurotoxic drug able to be used as a less harmful substitute for entactogenic drugs such as MDMA.".
- Q5269984 label "DiFMDA".
- Q5269984 depiction DFMDA.svg.