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- Q5198208 subject Q10195735.
- Q5198208 subject Q8661861.
- Q5198208 abstract "Cyclic di-GMP-II riboswitches (also c-di-GMP-II riboswitches) form a class of riboswitches that specifically bind cyclic di-GMP, a second messenger used in multiple bacterial processes such as virulence, motility and biofilm formation. Cyclic di-GMP II riboswitches are structurally unrelated to cyclic di-GMP-I riboswitches, though both have the same function.Cyclic di-GMP-II riboswitches were discovered by bioinformatics, and are common in species within the class Clostridia and the genus Deinococcus. They are also found in some other bacterial lineages. There is significant overlap between species that use cyclic di-GMP-I and cyclic di-GMP-II riboswitches, as both riboswitch classes are common in Clostridia.In Clostridium difficile strains, a cyclic di-GMP-II riboswitch is found adjacent to a group I catalytic intron. Group I introns are ribozymes that catalyze the splicing of the RNA molecule in which they are embedded. In the riboswitch-associated case, the outcome of the splicing reaction catalyzed by the intron is controlled by the riboswitch in response to cyclic di-GMP levels. The splicing reaction is also regulated in vitro by levels of guanosine triphosphate, since group I introns require a guanosine derivative for their activity.Group I introns function as part of selfish elements, where they reduce the likelihood that the element will negatively impact the fitness of the host by interrupting a protein-coding gene. However, the group I intron associated with a cyclic di-GMP-II riboswitch is not selfish since it seems to perform a useful function for the cell. They also show that natural cells use allosteric ribozymes to regulate gene expression, a mechanism commonly used in engineered aptamers but not previously observed in nature.Cyclic di-GMP-II riboswitches are a pseudoknotted structure. Most of these riboswitches conserve a kink turn structural motif that permits a bend in the relevant stem, presumably facilitating the pseudoknot. Several nucleotide positions are highly conserved, with many around the terminal loops involved in the pseudoknot interaction.".
- Q5198208 thumbnail C-di-GMP-II-update.svg?width=300.
- Q5198208 wikiPageWikiLink Q10195735.
- Q5198208 wikiPageWikiLink Q10876.
- Q5198208 wikiPageWikiLink Q11053.
- Q5198208 wikiPageWikiLink Q128570.
- Q5198208 wikiPageWikiLink Q132809.
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- Q5198208 wikiPageWikiLink Q237218.
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- Q5198208 wikiPageWikiLink Q310543.
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- Q5198208 wikiPageWikiLink Q392227.
- Q5198208 wikiPageWikiLink Q414976.
- Q5198208 wikiPageWikiLink Q418722.
- Q5198208 wikiPageWikiLink Q418840.
- Q5198208 wikiPageWikiLink Q422462.
- Q5198208 wikiPageWikiLink Q467410.
- Q5198208 wikiPageWikiLink Q5198209.
- Q5198208 wikiPageWikiLink Q5611164.
- Q5198208 wikiPageWikiLink Q7187.
- Q5198208 wikiPageWikiLink Q7432.
- Q5198208 wikiPageWikiLink Q8054.
- Q5198208 wikiPageWikiLink Q845326.
- Q5198208 wikiPageWikiLink Q8661861.
- Q5198208 wikiPageWikiLink Q899814.
- Q5198208 comment "Cyclic di-GMP-II riboswitches (also c-di-GMP-II riboswitches) form a class of riboswitches that specifically bind cyclic di-GMP, a second messenger used in multiple bacterial processes such as virulence, motility and biofilm formation.".
- Q5198208 label "Cyclic di-GMP-II riboswitch".
- Q5198208 depiction C-di-GMP-II-update.svg.