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- Q5183674 subject Q9089708.
- Q5183674 abstract "In molecular biology, the creb binding domain is a protein domain. It is the interlocking domain of the eukaryotic nuclear receptor coactivators CREBBP and P300. This interlocking domain forms a 3-helical non-globular array that forms interlocked heterodimers with its target.Nuclear receptors are ligand-activated transcription factors involved in the regulation of many processes, including development, reproduction and homeostasis. Nuclear receptor coactivators act to modulate the function of nuclear receptors. Coactivators associate with promoters and enhancers primarily through protein-protein contacts to facilitate the interaction between DNA-bound transcription factors and the transcription machinery. Many of these coactivators are structurally related, including CBP (CREB-binding protein, CREBBP) and P300. CBP and P300 both have histone acetyltransferase activity. CBP/P300 proteins function synergistically to activate transcription, acting to remodel chromatin and to recruit RNA polymerase II and the basal transcription machinery. CBP is required for proper cell cycle control, differentiation and apoptosis. The interaction of CBP/P300 with transcription factors involves several small domains. The IBiD domain in the C-terminal of CBP is responsible for CBP interaction with IRF-3, as well as with the adenoviral oncoprotein E1A, TIF-2 coactivator, and the IRF homologue KSHV IRF-1.".
- Q5183674 symbol "Creb_binding".
- Q5183674 thumbnail PDB_1zoq_EBI.jpg?width=300.
- Q5183674 wikiPageWikiLink Q103191.
- Q5183674 wikiPageWikiLink Q1036906.
- Q5183674 wikiPageWikiLink Q14599311.
- Q5183674 wikiPageWikiLink Q14880807.
- Q5183674 wikiPageWikiLink Q14911859.
- Q5183674 wikiPageWikiLink Q14914339.
- Q5183674 wikiPageWikiLink Q14914591.
- Q5183674 wikiPageWikiLink Q177900.
- Q5183674 wikiPageWikiLink Q18027992.
- Q5183674 wikiPageWikiLink Q180951.
- Q5183674 wikiPageWikiLink Q188941.
- Q5183674 wikiPageWikiLink Q19088.
- Q5183674 wikiPageWikiLink Q193161.
- Q5183674 wikiPageWikiLink Q193447.
- Q5183674 wikiPageWikiLink Q207609.
- Q5183674 wikiPageWikiLink Q208467.
- Q5183674 wikiPageWikiLink Q210861.
- Q5183674 wikiPageWikiLink Q224093.
- Q5183674 wikiPageWikiLink Q224180.
- Q5183674 wikiPageWikiLink Q40260.
- Q5183674 wikiPageWikiLink Q407384.
- Q5183674 wikiPageWikiLink Q425326.
- Q5183674 wikiPageWikiLink Q428148.
- Q5183674 wikiPageWikiLink Q540614.
- Q5183674 wikiPageWikiLink Q630950.
- Q5183674 wikiPageWikiLink Q6589727.
- Q5183674 wikiPageWikiLink Q7430.
- Q5183674 wikiPageWikiLink Q8054.
- Q5183674 wikiPageWikiLink Q896177.
- Q5183674 wikiPageWikiLink Q898273.
- Q5183674 wikiPageWikiLink Q9089708.
- Q5183674 wikiPageWikiLink Q913367.
- Q5183674 symbol "Creb_binding".
- Q5183674 type Biomolecule.
- Q5183674 type Protein.
- Q5183674 type Thing.
- Q5183674 type Q206229.
- Q5183674 type Q8054.
- Q5183674 comment "In molecular biology, the creb binding domain is a protein domain. It is the interlocking domain of the eukaryotic nuclear receptor coactivators CREBBP and P300. This interlocking domain forms a 3-helical non-globular array that forms interlocked heterodimers with its target.Nuclear receptors are ligand-activated transcription factors involved in the regulation of many processes, including development, reproduction and homeostasis.".
- Q5183674 label "Creb binding domain".
- Q5183674 depiction PDB_1zoq_EBI.jpg.