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- Q5055634 subject Q8802898.
- Q5055634 abstract "The CcdA/CCdB Type II Toxin-antitoxin system is one example of the bacterial toxin-antitoxin (TA) systems that encode two proteins, one a potent inhibitor of cell proliferation (toxin) and the other its specific antidote (antitoxin). These systems preferentially guarantee growth of plasmid-carrying daughter cells in a bacterial population by killing newborn bacteria that have not inherited a plasmid copy at cell division (post-segregational killing).The ccd system (control of cell death) of the F plasmid encodes two proteins, the CcdB toxin (101 amino acids) and the CcdA antidote (72 amino acids). The antidote or antitoxin prevents CcdB toxicity by forming a tight CcdA–CcdB complex. The target of CcdB is the GyrA subunit of DNA gyrase, an essential type II topoisomerase in Escherichia coli.CcdB protein is a topoisomerase poison from Escherichia coli. It is responsible for killing plasmid-free segregants, and interferes with the activity of DNA gyrase. It acts to inhibit partitioning of the chromosomal DNA.Regulation of the ccd operon by the CCdA/CCdB complex is dependent upon the ratio of the two molecules to each other in the complex: a (CcdA)2–(CcdB)2 complex binds the DNA of the operon thus repressing transcription, but when CcdB is in excess of CcdA de-repression occurs, whereas repression will occur when CcdA levels are greater than or equal to that of CcdB. As a model system, by ensuring an antidote–toxin ratio greater than one, this mechanism might prevent the harmful effect of CcdB in plasmid-containing bacteria.The Ccd and parD systems are found to be strikingly similar in terms of their structures and actions. The antitoxin protein of each system interacts with its cognate toxin to neutralise the activity of the toxin and in the process the complex of the two becomes an efficient transcription repressor.".
- Q5055634 symbol "CcdA".
- Q5055634 symbol "CcdB".
- Q5055634 thumbnail PDB_2vub_EBI.jpg?width=300.
- Q5055634 wikiPageExternalLink index.php.
- Q5055634 wikiPageWikiLink Q10876.
- Q5055634 wikiPageWikiLink Q139677.
- Q5055634 wikiPageWikiLink Q172778.
- Q5055634 wikiPageWikiLink Q177900.
- Q5055634 wikiPageWikiLink Q274160.
- Q5055634 wikiPageWikiLink Q3495384.
- Q5055634 wikiPageWikiLink Q37748.
- Q5055634 wikiPageWikiLink Q407828.
- Q5055634 wikiPageWikiLink Q420548.
- Q5055634 wikiPageWikiLink Q420927.
- Q5055634 wikiPageWikiLink Q425218.
- Q5055634 wikiPageWikiLink Q427492.
- Q5055634 wikiPageWikiLink Q8054.
- Q5055634 wikiPageWikiLink Q8066.
- Q5055634 wikiPageWikiLink Q8802898.
- Q5055634 symbol "CcdA".
- Q5055634 symbol "CcdB".
- Q5055634 type Biomolecule.
- Q5055634 type Protein.
- Q5055634 type Thing.
- Q5055634 type Q206229.
- Q5055634 type Q8054.
- Q5055634 comment "The CcdA/CCdB Type II Toxin-antitoxin system is one example of the bacterial toxin-antitoxin (TA) systems that encode two proteins, one a potent inhibitor of cell proliferation (toxin) and the other its specific antidote (antitoxin).".
- Q5055634 label "CcdA/CcdB Type II Toxin-antitoxin system".
- Q5055634 depiction PDB_2vub_EBI.jpg.