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- Q5018775 subject Q7222364.
- Q5018775 subject Q7483856.
- Q5018775 abstract "A calcimimetic is a drug that mimics the action of calcium on tissues, by allosteric activation of the calcium-sensing receptor that is expressed in various human organ tissues. Calcimimetics are used to treat secondary hyperparathyroidism (SHPT).In the treatment of SHPT patients on dialysis calcimimetics does not appear to affect the risk of early death. It does decrease the need for a parathyroidectomy but caused more issues with low blood calcium levels and vomiting.Cinacalcet is a calcimimetic and the only approved drug of this class. Cinacalcet mimics calcium at the parathyroid hormone receptor. This binding will increase the sensitivity of calcium-sensing receptors (CaSR) on the parathyroid gland. As a result of the receptor "thinking" there is sufficient calcium, PTH secretion will be reduced. Lower calcium levels will be seen as well.On August 25th, 2015 Amgen Inc. announced that it had submitted a New Drug Application with the United States Food and Drug Administration for a novel calcimimetic, Etelcalcetide (formerly AMG 416, velcalcetide, KAI-4169), for the treatment of SHPT in CKD patients on hemodialysis. Etcalcetide is administered intravenously thrice weekly at the end of each dialysis session. Etcalcetide binds to the CaSR on the parathyroid gland, which results in receptor activation and ultimately reduction in PTH.Calcimimetics can be used concomitantly with vitamin D therapy.Calcimimetic use can have side effects. Common side effects include: nausea and vomiting, hypocalcemia, and adynamic bone disease if iPTH levels drop below 100pg/mL.".
- Q5018775 wikiPageWikiLink Q127076.
- Q5018775 wikiPageWikiLink Q14860476.
- Q5018775 wikiPageWikiLink Q15321271.
- Q5018775 wikiPageWikiLink Q175621.
- Q5018775 wikiPageWikiLink Q186889.
- Q5018775 wikiPageWikiLink Q193978.
- Q5018775 wikiPageWikiLink Q202301.
- Q5018775 wikiPageWikiLink Q21098973.
- Q5018775 wikiPageWikiLink Q3269441.
- Q5018775 wikiPageWikiLink Q3622611.
- Q5018775 wikiPageWikiLink Q444264.
- Q5018775 wikiPageWikiLink Q470517.
- Q5018775 wikiPageWikiLink Q706.
- Q5018775 wikiPageWikiLink Q7136153.
- Q5018775 wikiPageWikiLink Q7222364.
- Q5018775 wikiPageWikiLink Q7483856.
- Q5018775 wikiPageWikiLink Q8386.
- Q5018775 wikiPageWikiLink Q845326.
- Q5018775 wikiPageWikiLink Q936382.
- Q5018775 comment "A calcimimetic is a drug that mimics the action of calcium on tissues, by allosteric activation of the calcium-sensing receptor that is expressed in various human organ tissues. Calcimimetics are used to treat secondary hyperparathyroidism (SHPT).In the treatment of SHPT patients on dialysis calcimimetics does not appear to affect the risk of early death.".
- Q5018775 label "Calcimimetic".