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- Q5008164 subject Q6980517.
- Q5008164 abstract "C3b is the larger of two elements formed by the cleavage of complement component 3, and is considered an important part of the innate immune system. C3b is potent in opsonization:tagging pathogens, immune complexes (antigen-antibody), and apoptotic cells for phagocytosis. Additionally, C3b plays a role in forming a C3 convertase when bound to Factor B (C3bBb complex), or a C5 convertase when bound to C4b and C2a (C4b2a3b complex) or when an additional C3b molecule binds to the C3bBb complex (C3bBb3b complex).C3b's ability to perform these important functions derives from its ability to covalently bind to the surface of invading pathogens within an organism's body. The cleavage of C3 leaves C3b with an exposed thioester bond, allowing C3b to effectively coat and tag foreign cells by covalently binding to hydroxyl (-OH) and amine (-NH2) groups on foreign cell surfaces.This cleavage can occur via three mechanisms (classical pathway, alternative pathway and mannose binding lectin) that ultimately lead to the formation of a C3 convertase. Formation of a C3 convertase functions as a positive feedback loop, so as more C3b is cleaved, more C3 convertases are formed, further amplifying the signal on the surface the microbial invader. This amplification of signal serves as a powerful tool for the immune system in effective clearance of the invading pathogen.".
- Q5008164 thumbnail Complement_pathway.svg?width=300.
- Q5008164 wikiPageExternalLink ch163d.html.
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- Q5008164 wikiPageWikiLink Q5008114.
- Q5008164 wikiPageWikiLink Q5008394.
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- Q5008164 wikiPageWikiLink Q6980517.
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- Q5008164 wikiPageWikiLink Q79451.
- Q5008164 wikiPageWikiLink Q79460.
- Q5008164 wikiPageWikiLink Q929966.
- Q5008164 comment "C3b is the larger of two elements formed by the cleavage of complement component 3, and is considered an important part of the innate immune system. C3b is potent in opsonization:tagging pathogens, immune complexes (antigen-antibody), and apoptotic cells for phagocytosis.".
- Q5008164 label "C3b".
- Q5008164 depiction Complement_pathway.svg.