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- Q4994856 subject Q4926419.
- Q4994856 subject Q7217197.
- Q4994856 subject Q7469321.
- Q4994856 abstract "In the field of genetics, Cre-Lox recombination is known as a site-specific recombinase technology, and is widely used to carry out deletions, insertions, translocations and inversions at specific sites in the DNA of cells. It allows the DNA modification to be targeted to a specific cell type or be triggered by a specific external stimulus. It is implemented both in eukaryotic and prokaryotic systems. The Cre-lox recombination system has been particularly useful to help neuroscientists to study the brain in which complex cell types and neural circuits come together to generate cognition and behaviors. NIH Blueprint for Neuroscience Research has created several hundreds of Cre driver mouse lines which are currently used by the world-wide neuroscience community.The system consists of a single enzyme, Cre recombinase, that recombines a pair of short target sequences called the Lox sequences. This system can be implemented without inserting any extra supporting proteins or sequences. The Cre enzyme and the original Lox site called the LoxP sequence are derived from bacteriophage P1.Placing Lox sequences appropriately allows genes to be activated, repressed, or exchanged for other genes. At a DNA level many types of manipulations can be carried out. The activity of the Cre enzyme can be controlled so that it is expressed in a particular cell type or triggered by an external stimulus like a chemical signal or a heat shock. These targeted DNA changes are useful in cell lineage tracing and when mutants are lethal if expressed globally.The Cre-Lox system is very similar in action and in usage to the FLP-FRT recombination system.".
- Q4994856 thumbnail Cre_Lox71-66_Recombination_Method.png?width=300.
- Q4994856 wikiPageExternalLink introduction.html.
- Q4994856 wikiPageWikiLink Q1070877.
- Q4994856 wikiPageWikiLink Q1148110.
- Q4994856 wikiPageWikiLink Q12321.
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- Q4994856 wikiPageWikiLink Q165028.
- Q4994856 wikiPageWikiLink Q1650834.
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- Q4994856 wikiPageWikiLink Q211675.
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- Q4994856 wikiPageWikiLink Q284398.
- Q4994856 wikiPageWikiLink Q310425.
- Q4994856 wikiPageWikiLink Q408483.
- Q4994856 wikiPageWikiLink Q412550.
- Q4994856 wikiPageWikiLink Q423026.
- Q4994856 wikiPageWikiLink Q4348580.
- Q4994856 wikiPageWikiLink Q4926419.
- Q4994856 wikiPageWikiLink Q4955858.
- Q4994856 wikiPageWikiLink Q531306.
- Q4994856 wikiPageWikiLink Q53832.
- Q4994856 wikiPageWikiLink Q5426559.
- Q4994856 wikiPageWikiLink Q591576.
- Q4994856 wikiPageWikiLink Q615868.
- Q4994856 wikiPageWikiLink Q656732.
- Q4994856 wikiPageWikiLink Q7217197.
- Q4994856 wikiPageWikiLink Q7430.
- Q4994856 wikiPageWikiLink Q7469321.
- Q4994856 wikiPageWikiLink Q7531735.
- Q4994856 wikiPageWikiLink Q8066.
- Q4994856 wikiPageWikiLink Q908966.
- Q4994856 wikiPageWikiLink Q916504.
- Q4994856 comment "In the field of genetics, Cre-Lox recombination is known as a site-specific recombinase technology, and is widely used to carry out deletions, insertions, translocations and inversions at specific sites in the DNA of cells. It allows the DNA modification to be targeted to a specific cell type or be triggered by a specific external stimulus. It is implemented both in eukaryotic and prokaryotic systems.".
- Q4994856 label "Cre-Lox recombination".
- Q4994856 depiction Cre_Lox71-66_Recombination_Method.png.